Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women

Yamada, Kento; Isobe, Satoshi; Hirai, Makoto; Unno, Kazumasa; Ohshima, Satoru; Takada, Yasuo; Izawa, Hideo; Abe, Kazutoshi; Yokota, Mitsuhiro; Murohara, Toyoaki

doi:10.1007/bf02984679

“…We further found an impairment of LV contractile reserve in older females after adenosine stress when categorized age groups were compared, a phenomenon that was not observed in men. Interestingly, similar post-exercise changes in cardiac performance have previously been observed in postmenopausal women and in diabetic patients [18][19][20][21]. LV diastolic decompensation or sub-endocardial ischemia following pharmacological stress could account for these observations [22], however, determining what factors play a key role in the depression of LV contractile reserve in aged women warrants further investigation.…”

Section: Discussionsupporting

confidence: 52%

Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT

Gebhard

¹

,

Stähli

²

,

Gebhard

³

et al. 2014

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Gender- and age-related changes of left ventricular (LV) function and dimensions have not been elucidated in a large population by gated SPECT. Thus, the aim of this study was to derive male and female reference limits for left ventricular functional parameters, and determine the effect of age on LV dimensions and systolic function for this imaging modality. 1,639 (53% males) subjects without cardiovascular disease who underwent cardiac SPECT between January 2002 and June 2012 were included in this study. Mean age at presentation was 61 ± 12 years (range 18-92 years). A significant effect of age (p = 0.011) and gender (p < 0.0001) on resting LV ejection fraction (LVEF) was observed, with an increase in LVEF with age being more pronounced in women (ΔB-coefficient: -0.088, p = 0.011). Overall, mean LVEF was higher in women compared to men (70.3 ± 8.6% vs. 64.4 ± 7.5%, p < 0.0001). LVEF after pharmacological stress with adenosine was significantly lower than at rest in both women and men (∆LVEF = 1.1% in males and ∆LVEF = 1.6% in females, p = 0.01), which was the result of a significant increase in end-systolic volume after stress (p = 0.0001). With advancing age an increase in LVEF was observed that was more pronounced in women than in men. These findings indicate that the evaluation of cardiac function and volumes of patients by gated SPECT should consider age- and gender-matched normative values.

show abstract

“…According to the study by Alexanderson-Rosas et al, cardiac systolic function is decreased in menopausal women [ 7 ]. There are also studies suggesting that LVEF increases in early menopausal women, while diastolic function decreases [ 8 ]. Basic research has also addressed the issue of abnormal cardiac function in OVX animal models, and it is believed that various cardiac function parameters of OVX rats have abnormal changes [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent cross-sectional study showed that postmenopausal women undergo a series of pathological changes, such as inflammatory responses and vasodilatory dysfunction, due to E 2 deficiency that leads to a decrease in myocardial contractile function [ 7 ]. However, it has also been reported that the decline in E 2 levels in women in early menopause (within 1 year) actually increases LVEF and decreases diastolic function [ 8 ]. Specifically, in a certain period of menopause, the cardiac function status of women may vary with the time of menopause.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Evolution of Cardiac Function and Glucose and Lipid Metabolism in Ovariectomized Rats and the Intervention Effect of Erxian Decoction

Wang

¹

,

Jiang

²

,

Hu

³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

3

0

View full text Add to dashboard Cite

Aims. Abnormal changes in cardiac function have been reported in menopausal women, but there are few clinical studies on this topic. Erxian decoction (EXD) is a classic prescription that is widely used in the treatment of female menopausal diseases. The purpose of this study was to investigate the dynamic evolution of cardiac function and glucose and lipid metabolism in ovariectomized (OVX) rats and the intervention effect of EXD. Materials and Methods. The OVX climacteric rat model was established by bilateral ovariectomy. After successful modeling, the rats were randomly divided into four groups: the sham operation (SHAM) group (equal volumes of purified water), OVX group (equal volumes of purified water), estradiol (E2) group (1.8 × 10−4 g/kg), and EXD group (9 g/kg). Each group of rats was treated for 16 weeks. At the 4th, 8th, 12th, and 16th weeks after treatment, the cardiac function of the rats in each group was evaluated by ultrasound. The coaxial method was used to measure blood pressure (BP). Serum endothelin-1 (ET-1) and angiotensin-2 (Ang II) levels were determined by the enzyme-linked immunosorbent assay (ELISA). The strip method was used to measure fasting blood glucose (FBG). The serum total cholesterol (TC) and triglyceride (TG) levels of rats were measured with the oxidase method. Direct methods were used to measure serum high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels. At week 16 of dosing, serum E2 levels were determined by E2 radioimmunoassay. The myocardium and uterus of the rats in each group were stained with HE (hematoxylin-eosin). The ultrastructure of the rat myocardium was observed by electron microscopy. Results. After the 16th week of treatment, the serum E2 level decreased ( P < 0.05 ), and the uterus was atrophied in OVX rats. The cardiac ejection fraction (EF%) decreased at 4 weeks after treatment, and systolic and diastolic function decreased after 12 weeks. After the 16th week, the EF%, which reflects the “pump” function of the heart, decreased significantly ( P < 0.05 or P < 0.01 ). At the 4th, 8th, 12th, and 16th weeks of treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean pressure (MBP) of the rats in the OVX group increased with time ( P < 0.05 or P < 0.01 ). The serum ET-1 and Ang II levels of rats in the OVX group increased ( P < 0.05 or P < 0.01 ). In the OVX group, FBG was increased ( P < 0.05 or P < 0.01 ), and blood lipids, especially LDL-C, were significantly increased ( P < 0.05 or P < 0.01 ). After the 16th week of treatment, the myocardial tissue of OVX rats showed obvious pathological changes. EXD significantly increased serum E2 levels ( P < 0.01 ), decreased ET-1 and Ang II levels ( P < 0.01 ), reduced the cardiac function risk factors BP, FBG, and blood lipids, and significantly improved cardiac function and structural changes in OVX rats ( P < 0.05 or P < 0.01 ). Conclusions. EXD can improve abnormal cardiac structure and function in OVX rats.

show abstract

“…De fato, foi demonstrado que a angiotensina II estaria envolvida em adaptações inadequadas na morfometria cardíaca e redução da angiogênese, acompanhadas pelo aumento na expressão cardíaca dos receptores AT1 e AT2. Todos esses fatores acarretariam prejuízos para a hemodinâmica cardíaca (BARBAGALLO et al, 1995;PRIME et al, 2007;HERNÁNDEZ et al, 1998;PATTEN & KARAS, 2006;YAMADA et al, 2006;KEIDAR et al, 2007). No entanto, a participação do SRAA nesse processo apresenta resultados contraditórios.…”

Section: Hormônios Ovarianos E Sistema Renina-angiotensina-aldosteronaunclassified

Estudo experimental da participação do sistema renina angiotensina-aldosterona nas adaptações hemodinâmicas e morfofuncionais cardíacas provocadas pela falência ovariana - efeito do treinamento físico aeróbio

Fares¹

0

View full text Add to dashboard Cite

Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women

Abstract: An age-related change in cardiac performance is apparent at an approximately 1 year follow-up in postmenopausal women. In particular, the increase in LV systolic function tends to show the greatest value in the 50s subjects among the 3 generations.

Cited by 5 publications

References 11 publications

Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT

Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT

Dynamic Evolution of Cardiac Function and Glucose and Lipid Metabolism in Ovariectomized Rats and the Intervention Effect of Erxian Decoction

Estudo experimental da participação do sistema renina angiotensina-aldosterona nas adaptações hemodinâmicas e morfofuncionais cardíacas provocadas pela falência ovariana - efeito do treinamento físico aeróbio

Contact Info

Product

Resources

About