Changes with aging of steroidal levels in the cerebrospinal fluid of women

Murakami, Koichi; Nakagawa, Toshinobu; Shozu, Makio; Uchide, Kiyoshi; Koike, Koji; Inoue, Masakí

doi:10.1016/s0378-5122(99)00040-7

Cited by 24 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The levels of free and conjugated steroids are shown in Table 6. Table 7 shows a comparison of our results with the data of other authors [9][10][11][12][13][14][15][16][17][18][19]. Our data from GC-MS analysis are in fair agreement with the GC-MS results of other studies, which is most apparent in Preg showing very close values to the data of Uzunova et al [16].…”

Section: Resultssupporting

confidence: 89%

Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances

Kancheva

Hill

Novák

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 89%

Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances

Kancheva

Hill

Novák

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

“…These are common problems in studies of delirium pathophysiology. It is important that control groups are age-matched, to control for physiological changes with age; age-specific reference ranges for most biomarkers in CSF have not been determined, and many of these systems including the hypothalamic-pituitary-adrenal axis and immune system change with age [35][36][37] . Also, unless a biomarker is known only to originate from the CNS, co-measurement of the biomarker in a paired serum sample helps to estab-lish whether it has been produced predominantly in the CNS or whether high peripheral levels may have led, in some cases, to increased passage into the CNS, for example in the event of blood-brain barrier compromise in sepsis [38,39] .…”

Section: Discussionmentioning

confidence: 99%

A Systematic Literature Review of Cerebrospinal Fluid Biomarkers in Delirium

Hall¹,

Shenkin²,

MacLullich³

2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology. Methods: A systematic literature review of CSF studies of DSM or ICD delirium was performed. Results: In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, β-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features. Conclusions: No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies.

show abstract

“…Es ist nicht zutreffend, ihr Auftreten mit dem absoluten Östrogenmangel in Verbindung zu bringen. In der Prämenopause können sogar vorübergehend erhöhte Östrogenspiegel auftreten, und es muss vielmehr der intermittierende rasche Abfall des Östra-diolspiegels und eine demzufolge auftretende Instabilität im zentralen serotoninergen System als auch anderer an diesem System beteiligter Neurotransmitter betrachtet werden [1, 10,14]. So empfinden z.…”

Section: Ursachen Und Verlaufunclassified

Periklimakterium

Braendle

2004

Gyn�kologische Endokrinologie

View full text Add to dashboard Cite

Als Periklimakterium wird die Phase ab dem Zeitpunkt bezeichnet, in dem Stö-rungen beginnen, die noch nicht die typischen Symptome des Klimakteriums sind -meist unregelmäßige Blutungen, verlängerte Zyklen mit verstärkten Abbruchblutungen aufgrund von Follikelpersistenzen einhergehend mit einer erhöhten Östrogenbiosynthese. Der typische klimakterische Beschwerdekomplex ist dann geprägt von Hitzewallungen, Schweißausbrüchen, die stark belastend sein können, bei nächtlichem Auftreten grundsätzlich mit Schlafstö-rungen verbunden sind und so zu Mü-digkeit, Antriebslosigkeit und zu depressiven Verstimmungen führen können. DefinitionDas Periklimakterium entspricht der Lebensphase, in der die typischen Symptome der nachlassenden ovariellen Funktion erlebt werden.Dies betrifft in den meisten Fällen die Zeit zwischen dem 45. und 55.Lebensjahr.Die Veränderungen,die in dieser Phase stattfinden, einer Periode, die wesentlich länger dauert als der subjektiv empfundene klimakterische Beschwerdekomplex,betreffen viele Organsysteme [2,8].▃ Das Nachlassen der Ovarialfunktion zieht sich über Jahre hin Im Vordergrund steht zunächst die Unregelmäßigkeit und dann das endgültige Sistieren der zyklischen Ovarialfunktion. Leitthema W. Braendle Zentrum für Frauen-,Kinder-und Jugendmedizin,Poliklinik für gynäkologische Endokrinologie und Reproduktionsmedizin,Hamburg Häufigkeit menopausaler Symptome bei Frauen zwischen dem 45. und 55. Lebensjahr. (Nach [7]) Symptom Häufigkeit [%] Wallungen Periklimakterium. Ab wann hormonelle Therapie?estrogens and progestins,mostly in sequential application;hysterectomized women should be treated only with estrogens.Only if this hormone therapy can be demonstrated to suppress the disturbing symptoms is further treatment indicated. AbstractThe periclimacteric period is not exactly defined. It is the period where symptoms are found connected to the decrease of the endocrine ovarian function,but are not yet typical for the climacteric syndrome such as hot flashes.On the other hand,hot flashes can occur when menstrual cycles are still regular.The hypothesis for an endocrine correlation is irritation in the cerebral function in the central regulatory unit due to possibly only locally disturbed endocrine action.Depending on their severity,the symptoms are an indication for treatment with progestins or

show abstract

Changes with aging of steroidal levels in the cerebrospinal fluid of women

Cited by 24 publications

References 40 publications

Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances

Peripheral neuroactive steroids may be as good as the steroids in the cerebrospinal fluid for the diagnostics of CNS disturbances

A Systematic Literature Review of Cerebrospinal Fluid Biomarkers in Delirium

Periklimakterium

Contact Info

Product

Resources

About