Changes with Time in the Oral Microflora and Dental Caries Induction in Hyposalivated Rats Fed on Sucrose Diet

Rampant dental caries was induced in hyposalivated rats fed a high sucrose diet without infection of mutans streptococci, in which increased numbers of lactobacilli and S. aureus were demonstrated in the oral flora. Administration of either penicillin or piperacillin, effective against all isolates of lactobacilli, markedly inhibited the caries induction in these rats, while severe dental caries was induced in hyposalivated rats given vancomycin that is inhibitory against S. aureus. These results suggested that certain lactobacilli might induce dental caries in hyposalivated rats fed a sucrose diet. Three strains of Lactobacillus species isolated from the hyposalivated rats were made resistant to erythromycin. The caries-inducing activity of these erythromycin-resistant lactobacilli was studied in hyposalivated rats giving erythromycin in the drinking water at a concentration of 500 fig/ml. After a 61-day experimental period, severe dental caries was induced in hyposalivated rats infected with L. fermentum TY1R. On the other hand, low caries incidence was found in hyposalivated rats infected with either L. acidophilus TY7R or L. plantarum TY3R. These results indicate that L. fermentum may be one of causative agents of dental caries in hyposalivated rats fed a sucrose diet.

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Prompted secretion of salivary polypeptides by the submandibular glands of rats on cariogenic diets.

Kabashima

Motokawa

Ishibashi

et al. 1996

Jpn J Oral Biol

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Abstract:The effects of cariogenic diets on salivary polypeptides secretion by the submandibular glands of SD rats were investigated. Cariogenic diets (Diet 2000 adjusted sucrose concentration to 56%) were administered to experimental rats at 3 weeks of age for 7 weeks and MF powder chow administered to controls. Submandibular saliva was intra-orally collected by the cannulation method for 1h. Octopamine (OCT) and isoproterenol (IPR) were used as sialogogues.

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Changes with Time in the Oral Microflora and Dental Caries Induction in Hyposalivated Rats Fed on Sucrose Diet

Abstract: The effects of hyposalivation on the induction of dental caries and the change in oral microflora were examined at weekly intervals in Sprague-Dawley

Cited by 3 publications

References 24 publications

Caries-related factors and bacterial composition of supragingival plaques in caries free and caries active Algerian adults

Caries-related factors and bacterial composition of supragingival plaques in caries free and caries active Algerian adults

Detection of Caries‐Inducing Microorganisms in Hyposalivated Rats without Infection of Mutans Streptococci

Prompted secretion of salivary polypeptides by the submandibular glands of rats on cariogenic diets.

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