By engaging the focus of today's students, who are immersed in technology from birth, the employment of Web 2.0 tools in the educational process enriches learning environments. Because of this, the purpose of this study is to ascertain the impact of course materials created using Web 2.0 applications on the academic achievement and attitudes of 10th-grade chemistry students in the unit on "Acids, Bases, and Salts." One of the quantitative research techniques used in this study is a quasi-experimental design with a pre-and post-test control group. For this reason, students in the experimental group who used course materials developed by Web 2.0 applications and the control group who used the traditional teaching technique had their academic achievement scores and attitudes in the chemistry course compared. 48 students in the 10th grade from a public high school in the Yüreğir district of the province of Adana participated in the study, and the application procedure lasted for a total of 9 weeks. The academic achievement test post-test scores of the experimental and control groups showed a statistically significant difference in favor of the experimental group, according to the analysis's findings, whereas there was no statistically significant difference between the chemistry attitude scores. These findings revealed that students' achievement in chemistry was raised by activities created using Web 2.0 tools.