Changing Concepts in Polycystic Ovarian Syndrome

Roy, Madhu; Yasmin, Sanjida

doi:10.1016/s0976-0016(11)60531-0

Cited by 1 publication

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has a reproductive, metabolic and cardiovascular health complication across the lifespan. It is also defined as a presence of 12 or more follicles on ultrasound sonography 30 . Insulin resistance, with compensatory hyperinsulinemia, plays a major role in the metabolic abnormalities associated with PCOS.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome

Kakadia¹,

Patel²,

Deshpande³

et al. 2019

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

The clinical management of PCOS is multifaceted but often unsatisfactory. The aim of the current study is to evaluate the effect of Vitex negundo L. in the letrozole-induced polycystic ovarian syndrome. Female Sprague-Dawley rats were divided into six groups, each containing 6 animals. Group I (Control) daily received 1% carboxymethylcellulose (CMC) suspension as a vehicle control. Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS in Group II to VI. PCOS induced animals were treated with aqueous (Group III - 200 mg/kg and IV- 400 mg/kg) and hydroalcoholic extract (Group V- 200 mg/kg and VI- 400 mg/kg) of Vitex negundo up to 66 days using 0.5% w/v CMC as the vehicle. Body weight and estrous cycle phase were measured every day. Blood samples were collected on 0, 21 and 66 days for the measurement of fasting blood glucose, lipid profile, LH, FSH and hormonal level. Oral glucose tolerance test was performed to study insulin resistance effect. Toxicity markers; SGOT, SGPT, and creatinine also measured at the end of the study. The administration of Letrozole led to an abnormality in serum sex steroid profile, lipid profile, glucose and estrous cycle. It was able to successfully exert its protective effect by restoring parameters to the normal level and disappearance of cysts in ovaries. This can be attributed to phyto-components present in the extract. The aqueous and hydro-alcoholic extracts of seeds of Vitex negundo showed significant amelioration of Letrozole induced PCOS.

show abstract

Section: Discussionmentioning

confidence: 99%