Changing demographics of cervical cancer in the United States (1973–2007)

Ward, Kevin; Saenz, Cheryl C.; McHale, Michael; Alvarez, E; Plaxe, Steven C.

doi:10.1016/j.ygyno.2011.07.039

Cited by 7 publications

(11 citation statements)

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“…Currently, it also is the only cancer that has a definite cause that can be treated early and prevented -and then eradicated. High-risk HPV persistent infections are the main causes of cervical cancer and precancerous lesions (Pierce Campbell et al, 2012;Ward et al, 2012). Another study reported positive HPV infections in up to 99.7% of cervical cancer tissue specimens (Miura et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiology and basic research have confirmed that human papillomavirus (HPV) infection is a major cause of cervical intraepithelial neoplasia and cervical cancer (Pierce Campbell et al, 2012;Ward et al, 2012). HPV infection has a strong regionalism, and HPV infection rates and distribution in different countries or regions are different (Clifford et al, 2005); therefore, studying the distribution of HPV in a particular region provides important guidance for developing and applying vaccines.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We studied human papillomavirus (HPV) prevalence and genotype distribution among women in the Henan Province to provide epidemiological data as a means of preventing cervical cancer and developing a vaccine. A total of 14,873 samples were genotyped by using polymerase chain reaction reverse dot-blot. The overall HPVpositive rate in the sample was 23.98% (3566/14873), of which 69.01% (2461/3566) were infected with high-risk HPV types and 17.33% (618/3566) with low-risk types. Eighteen high-risk HPV types were detected; HPV 16 (16.73%) was the most common, followed by 58 (10.17%), 52 (9.11%), 56 (6.48%), 66 (5.76%), 33 (4.74%), 68 (3.92%), 31 (3.60%), 53 (3.13%), 59 (3.00%), 35 (2.53%), 51 (2.00%), 73 (1.08%), 45 (0.94%), 83 (0.84%), 39 (0.69%), 18 (0.61%), and MM4 (0.04%). Four low-risk HPV types were detected; HPV 43 (11.34%) was the most common, followed by 6 (5.17%), 42 (4.76%), and 11 (3.35%). 5452-5461 (2015) tions, of which 20.11% (717/3566) had double HPV infections. One peak in HPV prevalence occurred among women younger than age 25; a second peak occurred among women older than age 55. The overall prevalence of HPV infection in the Henan Province was 23.98%, of which the most common type was high-risk HPV and a single type of infection. The leading genotypes were HPV 16, 43, 58, 52, and 56.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

et al. 2015

Genet. Mol. Res.

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“…It is noteworthy, however, that the only observed PR on this trial was in a case of adenocarcinoma of the cervix. Unlike squamous cell carcinoma of the cervix, which is decreasing in incidence in industrialized nations due to the effectiveness of population based screening programs, the incidence of invasive adenocarcinoma of the cervix has been increasing [24]. Adenocarcinoma of the cervix, while relatively understudied, appears to be distinct from squamous cervical cancer, with a greater propensity for systemic dissemination, possibly benefiting less from radiotherapy, a suggestion of higher responsiveness to chemotherapy, and a worse prognosis than squamous cervical cancer in advanced stages [25].…”

Section: Discussionmentioning

confidence: 99%

Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)

Tinker

Ellard

Welch

et al. 2013

Gynecologic Oncology

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“…Tumor metastasis results in ~90% of cancer-related deaths (21,22). For cervical cancer, invasion and migration are important processes in the progression of cancer metastasis (23). Therefore, studies on molecular mechanisms underlying tumor invasion and metastasis are very relevant for understanding tumor occurrence and development.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of Trio by CRISPR/Cas9 suppresses migration and invasion of cervical cancer cells

et al. 2017

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Triple functional domain protein (Trio) is an evolutionarily conserved protein with guanine nucleotide exchange factors that regulate different physiological processes in some types of cancer. However, the expression and function of Trio in cervical cancer are still unknown. The purpose of this study was to detect the expression of Trio in cervical cancer tissues and to evaluate its clinical value. Furthermore, the effects of the Trio on the migration and invasion of cervical cancer cells and its mechanism were investigated in vitro. The results of the present study revealed that Trio expression levels were significantly higher in most of the clinical cervical cancer samples than in adjacent tissues. The clinicopathological significance of Trio expression was also analyzed, and the results revealed that high expression levels in cervical cancer were correlated with lymph node metastasis (P=0.005). The CRISPR/Cas9 system was used to knockdown the endogenous Trio. The inhibition of Trio significantly decreased the migration and invasion abilities of cervical cancer cells. Meanwhile, levels of RhoA/ROCK signaling factors (RhoA, Rock, and p-LIMK), which contributed to cell migration and invasion, were decreased along with the inhibition of Trio. Therefore, Trio may regulate the migration and invasion of cervical cancer through the RhoA/ROCK signaling pathway.

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Changing demographics of cervical cancer in the United States (1973–2007)

Cited by 7 publications

References 0 publications

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)

Knockdown of Trio by CRISPR/Cas9 suppresses migration and invasion of cervical cancer cells

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