Changing demography of prostate cancer in Asia

Sim, Hong Gee; Cheng, Christopher

doi:10.1016/j.ejca.2004.12.033

Cited by 259 publications

(208 citation statements)

References 73 publications

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“…Along with this, there has also been an increase in the number of patients with prostate cancer who face psychological distress in addition to their physical problems. 2 Depression, anxiety, posttraumatic stress symptoms, pain, sexual problems and difficulty in urinating, along with other symptoms, can potentially develop during both the initial and later stages of the disease. The management of these symptoms from a psychological point of view is essential when considering treatment alternatives for prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

Psychological aspects of prostate cancer: a clinical review

Sousa

Sonavane

Mehta

2012

Prostate Cancer Prostatic Dis

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Prostate cancer is the most common non-skin cancer in men. It is fraught with both physical and psychological symptomatology. Depression, anxiety, stress, fatigue, pain and psychosocial factors all affect the patient with prostate cancer. Impotence, erectile dysfunction, sexual issues and incontinence in these patients complicate matters further. Anxiety may exist both before testing and while awaiting test results. Confusion over choosing from various interventions often adds to anxiety and depression in these patients. Various demographic factors and the developmental stage of the couple affect these psychological symptoms. The caregiver may undergo significant psychological turmoil while caring for a patient diagnosed with prostate cancer, which is addressed. The role of nurses in the management of prostate cancer is discussed. The present review looks at psychological issues in patients with prostate cancer from a clinical perspective, with the aim of highlighting these issues for the clinical urologist dealing with these patients. It also explores the consultation --liaison relationship between psychiatrists, psychologists and urologists as a team for the multimodal management of prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Psychological aspects of prostate cancer: a clinical review

Sousa

Sonavane

Mehta

2012

Prostate Cancer Prostatic Dis

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“…1 In China, the detection rate of PCa is increasing rapidly because of the extension of life expectancy, the change of lifestyles and the improvement of clinical skills. 2 Subsequently, conquering this stubborn disease has significant effect on the improvement of the health of the global male population. On the basis of individual metabolites representing end points of the molecular pathways perturbed by events in the genome, transcriptome or proteome, newly emerging metabolite profile or metabolomics shows potential to monitor metabolite changes that characterize abnormal processes occurring in the progression of disease and might provide clues for the treatment and diagnosis of disease.…”

Section: Introductionmentioning

confidence: 99%

Efforts to resolve the contradictions in early diagnosis of prostate cancer: a comparison of different algorithms of sarcosine in urine

Cao

Zhu

et al. 2011

Prostate Cancer Prostatic Dis

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Controversial data on sarcosine as a promising biomarker for prostate cancer (PCa) detection are present. The objective was to clarify these discrepancies and reevaluate the potential value of sarcosine in PCa. Sarcosine algorithms (supernatant and sediment sarcosine/creatinine, supernatant and sediment log2 (sarcosine/alanine)) in urine samples from 71 untreated patients with PCa, 39 patients with no evidence of malignancy (NEM) and 20 healthy women and men were quantified by liquid chromatography/tandem mass spectrometry. Although any sarcosine algorithms were significantly higher in PCa patients than in NEM patients (all Po0.05), comparable sarcosine values were measured in healthy women and men. Additionally, neither biopsy Gleason score nor clinical T-stage were correlated with sarcosine algorithms (all P40.05), and receiver operating characteristic curve analysis indicated that the diagnostic power of any of sarcosine algorithms was nonsignificantly higher than that of serum and urine PSA, but nonsignificantly lower than prostate cancer antigen 3 (PCA3) and the percent-free PSA (%fPSA). Improved diagnostic performances were observed when any of sarcosine algorithms was combined with PCA3 or %fPSA. In conclusion, the predictive power of sarcosine in PCa is modest compared with PCA3 and %fPSA. Sarcosine, which awaits more validation before it reaches the clinic, could be included into the list of candidate PCa biomarkers.

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“…Prostate cancer (PCa) is one of the most common cancers in the Western world and has an increasing incidence in the Asian countries [1]. The androgen receptor (AR) is important in the development and progression of PCa [2].…”

Section: Introductionmentioning

confidence: 99%

The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer

Yu¹,

Lai²,

Xia³

et al. 2008

Asian J Androl

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The androgen receptor (AR) plays an important role in the development and progression of prostate cancer (PCa). Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads to the hormonerefractory state. The detailed mechanisms of the conversion from androgen dependence to androgen independence remain unclear. Several PCa cell lines were established to study the role of AR in PCa, but the results were often inconsistent or contrasting in different cell lines, or in the same cell line grown under different conditions. The cellular and molecular alteration of epithelial cells and their microenvironments are complicated, and it is difficult to use a single cell line to address this important issue and also to study the pathophysiological effects of AR. In this paper, we summarize the different effects of AR on multiple cell lines and show the disadvantages of using a single human PCa cell line to study AR effects on PCa. We also discuss the advantages of widely used epithelium-stroma co-culture systems, xenograft mouse models, and genetically engineered PCa mouse models. The combination of in vitro cell line studies and in vivo mouse models might lead to more credible results and better strategies for the study of AR roles in PCa.

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Changing demography of prostate cancer in Asia

Cited by 259 publications

References 73 publications

Psychological aspects of prostate cancer: a clinical review

Psychological aspects of prostate cancer: a clinical review

Efforts to resolve the contradictions in early diagnosis of prostate cancer: a comparison of different algorithms of sarcosine in urine

The diverse and contrasting effects of using human prostate cancer cell lines to study androgen receptor roles in prostate cancer

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