Changing epidemiology of candidemia in a medical center in middle Taiwan

Hii, Ing-Moi; Chang, Huilan; Lin, Li‐Chen; Lee, Yu-Lin; Liu, Yuag-Meng; Liu, Chun-Eng; Chen, Changhua; Cheng, Yu-Ren; Chang, Chun-Ming

doi:10.1016/j.jmii.2013.08.017

Cited by 48 publications

(53 citation statements)

References 26 publications

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“…Al comparar candidemias por C. albicans vs no albicans, las primeras presentan mayor gravedad clínica, con mayor frecuencia fueron diagnosticadas en pacientes en UPC, mayor score APACHE II y mayor necesidad de VMI, concordante con los datos reportados en la literatura 21 .…”

Section: Discussionunclassified

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Siri

Legarraga

García

et al. 2017

Rev. chil. infectol.

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60 years, 77,5% had at least one co-morbidity. Candida albicans was the species most frequently identified 55%, followed by C. glabrata 18.3%, C. tropicalis 11.7% and C. parapsilosis 9.2%. Comparing 2000-2006 vs 2007-2013, increased the frequency of C. parapsilosis among non-albicans and echinocandins prescription. Patients with C. albicans showed higher APACHE-II, more requirement for invasive mechanical ventilation, greater association with CVC, and shorter incubation time compared with non-albicans species. The 30-day mortality was 31.7%. Conclusions: During this 14-years period we observed that C. albicans was the predominant specie and more recently a change among C. non-albicans increasing C. parapsilosis and decreasing C. glabrata 30-days and attributable mortality decreased together with more echinocandins prescription.]]>

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Section: Discussionunclassified

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Siri

Legarraga

García

et al. 2017

Rev. chil. infectol.

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“…are a leading cause of bloodstream infection (BSI) and are associated with a high mortality rate ranging from 30.4 to 53.6 %, especially among immunocompromised patients and those with severe underlying disease (Kett et al, 2011;Puig-Asensio et al, 2014;Wisplinghoff et al, 2014;Hii et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

In vitro biofilm production of Candida bloodstream isolates: any association with clinical characteristics?

Pongrácz

Kálmán

Juhász

et al. 2016

Journal of Medical Microbiology

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Candida spp. are a leading cause of bloodstream infection (BSI) and are associated with high mortality rates. Biofilm production is a virulence factor of Candida spp., and has been linked with poor clinical outcome. The aim of our study was to assess biofilm production of Candida bloodstream isolates at our institute, and to determine whether in vitro biofilm production is associated with any clinical characteristics of infection. During the four-year study period, 93 cases of Candida BSI were analysed. The most frequently isolated species was C. albicans (66.7 %), followed by C. glabrata (9.7 %), C. parapsilosis (9.7 %), C. tropicalis (9.7 %) and C. krusei (4.3 %). Biofilm production was more prevalent among non-albicans Candida spp. (77.4 %) than C. albicans (30.6 %) (P50.02). Abdominal surgery was identified as a risk factor of BSI caused by biofilm producing non-albicans Candida isolates. No risk factors predisposing to bloodstream infection caused by a biofilm producing C. albicans isolate were identified. Biofilm production was not verified as a risk factor of mortality.

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“…In Europe: i) the incidence of CBSI ranges from 3 to 8.6 cases per 100,000 population per year [2]; ii) the mortality of candidemia is 38% in hospitalized patients, and in patients with malignancies up to 70% [3]. In Taiwan, CBSI are the second most common cause of hospitalacquired sepsis (after bacteremia by Staphylococcus species) [4]. In this region fungemia causes a very high rate (up to 70%) of mortality and a rise in price of treatment due to prolonged hospitalization and application of antifungal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Because of the existence of noncharacteristic symptoms and clinical signs, it is very important to consider the risk factors and predisposing diseases in patients. Well-known risk factors include hematological and endocrine diseases, acquired and congenital immunodeficiency, use of broad-spectrum antibiotics and immunosuppressant drugs (steroids), prolonged hospitalization, especially in ICUs, invasive medical procedures, parenteral nutrition, presence of a central venous catheter and hemodialysis [3,4]. CBSI are frequently associated with the formation of biofilms, growth of Candida organisms on medical devices such as venous or urinary catheters.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, nonalbicans species have become a more common cause of CBSI, primarily in patients with immunodeficiency and hematological diseases [1]. Candida parapsilosis predominates as a cause of CBSI in patients on hemodialysis with implanted catheters, in catheterassociated infections of neonates, which appears reasonable due to the fact that this species usually colonizes the skin [2,4]. Up to now there are no data concerning the incidence, characteristics of infections, risk factors and strain virulence characteristics of CBSI from the region of Niš, Serbia.…”

Section: Introductionmentioning

confidence: 99%

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Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

Stojanović

Stojanović-Radić

et al. 2016

J Infect Dev Ctries

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Introduction: Candida spp. frequently cause hospital-acquired bloodstream infections (BSI) with a high mortality rate (up to 70%). We analyzed the frequency, infection characteristics, potential predisposing factors, susceptibility to antifungal drugs, biofilm production and other virulence characteristics of Candida spp. isolates obtained from a tertiary care hospital in Niš, Serbia, during a one year period. Methods: Medical histories, characteristics of isolated strains and drug susceptibility, as well as the effect on the function of isolated macrophages and other virulence features were evaluated. The obtained results were subjected to student's t-test and multivariate statistical analyzes. Results: Herein we report an annual incidence of 3.65 cases of C. albicans, C. lusitaniae and C. lipolytica infections per 10 5 population. Out of eight isolated strains, two (25%) were shown to be strong biofilm producers, one (12.5%) caused hemolysis on blood agar and in two (25%) cases macrophages were able to completely eliminate the yeast colonies. Chronic kidney disease, diabetes, malignant and other diseases were present in 37.5, 62.5, 50 and 75%, respectively, in the study group. All patients with Candida BSI received antifungal therapy (amphotericin B), however, hospital mortality was observed in 25% of patients. Conclusions: Evaluation of local Candida epidemiology, antifungal susceptibility and virulence factors, as well as personalized patient risk factors are important for the surveillance of Candida BSI, especially in intensive care unit patients and may contribute to the improved options and outcome for patients with Candida BSI.

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Changing epidemiology of candidemia in a medical center in middle Taiwan

Cited by 48 publications

References 26 publications

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

In vitro biofilm production of Candida bloodstream isolates: any association with clinical characteristics?

Surveillance and characterization of Candida bloodstream infections in a Serbian tertiary care hospital

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