Changing epidemiology of gastroesophageal reflux disease in the Asian–Pacific region: An overview

Abstract

Gastroesophageal reflux disease (GERD) is a common disease in the West, which now appears to be also increasing in prevalence in the Asian Pacific region. The reasons for this changing epidemiology are two-fold: an increased awareness among doctors and patients, and/or a true increase in the prevalence of the disease. Prevalence rates of reflux esophagitis (RE) of up to 16% and prevalence of GERD symptoms of up to 9% have been reported in the Asian population. However, the frequency of strictures and Barrett's esophagus remain very low. Non-erosive reflux disease (NERD) appears to be the most common form of GERD among Asian patients accounting for 50-70% of cases with GERD. Among Asian patients differences can also be discerned among different ethnic groups. For example, in Malaysia where a multiracial society exists, RE is significantly more common among Indians compared to Chinese and Malays whereas NERD is more frequently seen in the Indian and Malays compared to the Chinese. The reasons for these differences are not known but may indicate both genetic factors and environmental factors peculiar to the particular racial group. GERD has also been increasing in the region demonstrating a time-lag phenomenon compared to the West. Differing predisposition to GERD among different ethnic groups would mean that such an increase would be more prominent among certain racial groups.

Endoskopi yapılan hastalarda eroziv reflü hastalığının sıklığı,endoskopik, klinik ve histopatolojik özellikleri ve Helicobacter pylori ile ilişkisi

“…Batı toplumlarında üst gastrointestinal sistem (GİS) endoskopisi yapılan hastaların %15-25'inde özofajit bulunduğu rapor edilmiştir (11). Asya' da yapılan çalışmalarda ise bu sıklığın %0.8-16.3 gibi çok daha az sıklıkta görüldüğü bildirilmekte ve batılaşmayla beraber sıklığın giderek arttığı iddia edilmektedir (11,12).…”

“…Asya' da yapılan çalışmalarda ise bu sıklığın %0.8-16.3 gibi çok daha az sıklıkta görüldüğü bildirilmekte ve batılaşmayla beraber sıklığın giderek arttığı iddia edilmektedir (11,12). Normal sağlıklı popülasyonun rutinde gastroskopiye gitmemesinden dolayı özofajitin gerçek prevalansını saptamak biraz daha zordur.…”

Typical symptoms rather than extraesophageal symptoms affect the quality of life in gastroesophageal reflux disease

“…In the Eastern world, 3-7% of the adult population complains of the symptoms once or more per week (3,4). However, its prevalence has gradually increased (5), and domestic research reports have also indicated increasing trends (6).…”

Esomeprazole regimens for reflux symptoms in Chinese patients with chronic gastritis

“…Recent studies have shown that the prevalence of GERD in Asia is increasing [4,5] . In China, the majority of patients with reflux symptoms are investigated by endoscopy and, if no clear endoscopic findings are identified, they are often diagnosed as having chronic gastritis (CG) rather than NERD because this diagnosis is thought to be more acceptable to the patient.…”