Changing Epidemiology of HCV and HBV Infections in Northern Italy

Fabris, Paolo; Baldo, Vincenzo; Baldovin, Tatjana; Bellotto, Emanuela; Rassu, Mario; Trivello, R.; Tramarin, Andrea; Tositti, Giulia; Floreani, Annarosa

doi:10.1097/mcg.0b013e318030e3ab

Cited by 76 publications

(64 citation statements)

References 26 publications

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“…These differences can be related to the variability in the prevalence of anti-HCV antibodies in the general population of these two Mediterranean countries, being much higher in Italy. 22,23 Our study also fails to demonstrate that male gender is a risk factor for HCC in PBC when considering the overall series from Italy and Spain, thus totaling the highest series published. This is opposed to results reported in other studies, 4,5,14-16 a discrepancy that can be explained from the duration of follow-up and the number of patients evaluated.…”

Section: Discussioncontrasting

confidence: 73%

Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis

et al. 2009

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The limited information and divergent results on the prevalence, incidence, and risk factors for hepatocellular carcinoma (HCC) in patients with primary biliary cirrhosis (PBC) may be due to the low prevalence of the disease and geographical and environmental differences. Therefore, we analyzed the incidence, prevalence, survival, and risk factors for HCC in patients with PBC from two European centers (389 from Barcelona, Spain, and 327 from Padova, Italy) followed up for 9.3 ؎ 6.5 years. Gender, age, smoking habit, alcohol consumption, presence of hepatitis B surface antigen (

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Section: Discussioncontrasting

confidence: 73%

Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis

et al. 2009

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“…Additionally, this prevalence is also similar to the rate found in adolescents with immunization rates up to 98% in the state (1.4% and 0.6%) Tonial et al, 2011), the rate reported in Portugal for adolescents with a mean age of 14 years old (0.6%) (Antunes, Macedo, Estrada, 2004), and the rate reported in Italy for individuals up to 24 years old (1.0%) (Fabris et al, 2008); however, it is inferior to the rate reported by Nascimento et al (2008) in first-time eligible blood-donors from north, northeast and southeast Brazil (2.9%) and to the rate found in blood donors in south Brazil (15.6%) (Martelli et al, 1999) and the MRF (4.5%) (Rosini et al, 2003).…”

Section: Discussionsupporting

confidence: 60%

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

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Treitinger

et al. 2012

Braz. J. Pharm. Sci.

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We investigated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) serological markers of infection in young adults from the metropolitan region of Florianópolis who were conscripts of the Air Base of Florianópolis in the state of Santa Catarina, Brazil. A population-based cross-sectional seroprevalence study was conducted with 371 young males during a one year period starting in June 2009. Demographic characteristics, socio-economic characteristics and possible risk factors to HBV and HCV were assessed. Blood samples were analyzed for HBsAg, anti-HBc, anti-HCV and anti-HBs through automated microparticle enzymatic immunoassays (Abbott®, AxSYM System, Wiesbaden, Germany). None of the participants showed positivity to HBsAg or anti-HCV. The prevalence of anti-HBc was 1.6% (95% CI 0.6 -3.5), and the prevalence of anti-HBs was 40.7% (95% CI 35.7 -45.9). Unsafe sex was associated with positive anti-HBc in a bivariate analysis. There was a very low prevalence of past HBV infection and no cases of past HCV infection in a young adult population in the metropolitan region of Florianópolis. The very low prevalence of markers of infection and risk factors indicates a very optimistic future with respect to HBV and HCV infection in this population.Uniterms: HBV. HCV. Hepatitis B. Hepatitis C. Seroprevalence.Este estudo teve como objetivo investigar a prevalência dos marcadores sorológicos de infecção pelo HBV e HCV em adultos jovens na Região Metropolitana de Florianópolis, conscritos da Base Aérea de Florianópolis, Santa Catarina, Brasil. Trata-se de um estudo soroepidemiológico transversal de base populacional com 371 adultos jovens, no período de um ano a partir de junho de 2009. Foram pesquisadas características sócio-econômicas e possíveis fatores de risco para HBV e HCV. As amostras de sangue foram analisadas quanto à presença de HBsAg, anti-HBc, anti-HCV e anti-HBs pelo método imunoensaio enzimático automatizado de micropartículas (Abbott®, Sistema AxSYM, Wiesbaden, Alemanha). Nenhum dos participantes demonstrou positividade para HBsAg ou anti-HCV. A prevalência do anti-HBc foi de 1,6% (IC 95% 0,6 -3,5) e do anti-HBs foi 40,7% (IC 95% 35,9). Relação sexual desprotegida associou-se com a positividade do anti-HBc na análise bivariada. Demonstrou-se prevalência muito baixa de infecção passada pelo HBV e ausência de HCV nesta população de adultos jovens na Região Metropolitana de Florianópolis. A particularidade desta prevalência muito baixa de marcadores de infecção e fatores de risco aponta para um quadro otimista em relação ao HBV e HCV no futuro para esta população.Unitermos: HBV. HCV. Hepatite B. Hepatite C. Soroprevalência.

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“…Tonial GC et al -HBV and vaccination in Itajaí, southern Brazil and also to ensuring an adequate allocation of financial resources 15 . Thus, the aim of this study was to determine the prevalence of HBV markers and assess hepatitis B vaccination coverage in voluntary adolescents, junior high (secondary school) students, in the City of Itajaí, State of Santa Catarina, Brazil.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B marker seroprevalence and vaccination coverage in adolescents in the City of Itajaí, State of Santa Catarina, Southern Brazil, in 2008

Tonial

Passos

Livramento

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Hepatitis B infection constitutes an important cause of morbidity and mortality worldwide. In Brazil, however, the current epidemiological situation is not clear. Considering the importance of establishing this prevalence, the aim of this study was to determine the prevalence of HBV markers in voluntary adolescents, junior high (secondary school) students, in the City of Itajaí, State of Santa Catarina, Brazil. Methods: A seroepidemiological, transverse study was conducted with 353 randomly chosen adolescents from elementary school in 2008. Blood samples were analyzed for HBsAg, anti-HBc and anti-HBs. All analyses were conducted by automated microparticle enzyme immunosorbent assay (Abbott®, AxSYM system, Deerfield, IL, USA), according to the manufacturer's instructions. Results: The prevalence of HBsAg was 0.6% (CI 95% 0.1 -2.0), that of anti-HBc was 1.1% (CI 95% 0.3 -2.9) and that of detectable anti-HBs was 83.6% (CI 95% 79.3 -87.3). Hepatitis B vaccination coverage was 97.5% (CI 95% 95.2 -98.8). Conclusions: These results demonstrate the success of the vaccination program against hepatitis B in the region studied and indicate that prevention strategies must be maintained and, if possible, expanded to contribute to the establishment of positive prevalence rates in all age groups.

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Changing Epidemiology of HCV and HBV Infections in Northern Italy

Cited by 76 publications

References 26 publications

Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Incidence, Risk Factors, and Survival of Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

Hepatitis B marker seroprevalence and vaccination coverage in adolescents in the City of Itajaí, State of Santa Catarina, Southern Brazil, in 2008

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