Changing gears in the treatment of bipolar disorder through integrated use of electronic devices

Panchal, Priyanka; Kim, Jihoon A.; Sankar, Anjali; Goldman, Danielle; Villa, Luca M; Millard, Hun; Carrubba, Erin; Lecza, Bernadette; Merikangas, Kathleen R.; Silverman, Wendy K.; Swartz, Holly A.; Blumberg, Hilary P.

doi:10.1111/bdi.13065

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Additionally, given the link between physical activity and suicidal ideation [ 40 ] future studies should also consider incoporating objective measures of physical activity to identify atypical patterns. Ecological studies using Ecological Momentary Assessment and other mobile technologies to measure core domains (e.g., mood, substance use, suicidal thoughts, sleep, physical activity) may be especially helpful in uncovering associations among risk factors and their direction of influence [ 41 , 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Fell on Black Days: Analyzing the Song Lyrics of Chris Cornell for Insight into Depression and Suicide

Conway,

McGrain,

Theodory

2023

IJERPH

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Chris Cornell was a guitarist, singer, songwriter, and pioneer of grunge music. Cornell struggled with mental illness and addiction and incorporated these themes into his song lyrics. At age 52, Cornell died by suicide in his hotel bathroom following a live performance. This mixed-methods study examines Cornell’s song lyrics for references to negative words and themes related to depression and suicide. Two coders independently reviewed lyrical transcripts to identify the primary theme, secondary theme(s), and valence (positive or negative). Sentiment analysis, a natural language processing technique, was used to examine word frequency and valence. Songs (N = 215) were predominantly (79%) negative and contained more negative (N = 3244, 56.1%) than positive (N = 2537, 43.9%) words. Thematic analysis by stage of career shows a narrowing focus on depression, failed relationships, and morbid thoughts. Themes of depressed mood, death, and suicide were common and increased by stage of career. By applying qualitative and quantitative techniques to song lyrics, this study revealed that Cornell’s songs reflect a narrative of negativity consistent with someone experiencing depression and thoughts of death and suicide. Like personal notes and poems, song lyrics may reflect symptoms of depression and suicidal thoughts warranting clinical attention.

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Section: Discussionmentioning

confidence: 99%

Fell on Black Days: Analyzing the Song Lyrics of Chris Cornell for Insight into Depression and Suicide

Conway,

McGrain,

Theodory

2023

IJERPH

View full text Add to dashboard Cite

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“…Future actigraphy research in BD could not only benefit the work of researchers aiming to further elucidate the neurobiological basis of BD, but also clinicians and patients, who may in the future be able to use real-time and longitudinal monitoring to identify personal rest-activity patterns and warning signs ( 35 , 125 ). Traditional modes of in-person clinical appointments at the temporal scale of weeks or months can benefit from the use of daily and on-going monitoring through digital technologies and passive activity sensors for their ability to provide longitudinal and prospective data, including interim data that may indicate need for more acute care ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

“…In order to better understand BD, digital technologies have been leveraged to noninvasively collect biometric parameters when individuals are in their everyday environments ( 32 , 33 ). Temporal profiles of rest and activity, measured with digital actigraphy methods, hold promise for elucidating a novel phenotypic marker for BD ( 34 , 35 ). Identification of a salient time-varying phenotypic marker for BD may also reveal pathophysiological mechanisms of BD, which ultimately could serve as the basis for novel detection, treatment, and prevention strategies.…”

Section: Introductionmentioning

confidence: 99%

Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy

et al. 2022

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BackgroundDisruptions in rest and activity patterns are core features of bipolar disorder (BD). However, previous methods have been limited in fully characterizing the patterns. There is still a need to capture dysfunction in daily activity as well as rest patterns in order to more holistically understand the nature of 24-h rhythms in BD. Recent developments in the standardization, processing, and analyses of wearable digital actigraphy devices are advancing longitudinal investigation of rest-activity patterns in real time. The current systematic review aimed to summarize the literature on actigraphy measures of rest-activity patterns in BD to inform the future use of this technology.MethodsA comprehensive systematic review using PRISMA guidelines was conducted through PubMed, MEDLINE, PsycINFO, and EMBASE databases, for papers published up to February 2021. Relevant articles utilizing actigraphy measures were extracted and summarized. These papers contributed to three research areas addressed, pertaining to the nature of rest-activity patterns in BD, and the effects of therapeutic interventions on these patterns.ResultsSeventy articles were included. BD was associated with longer sleep onset latency and duration, particularly during depressive episodes and with predictive value for worsening of future manic symptoms. Lower overall daily activity was also associated with BD, especially during depressive episodes, while more variable activity patterns within a day were seen in mania. A small number of studies linked these disruptions with differential patterns of brain functioning and cognitive impairments, as well as more adverse outcomes including increased suicide risk. The stabilizing effect of therapeutic options, including pharmacotherapies and chronotherapies, on activity patterns was supported.ConclusionThe use of actigraphy provides valuable information about rest-activity patterns in BD. Although results suggest that variability in rhythms over time may be a specific feature of BD, definitive conclusions are limited by the small number of studies assessing longitudinal changes over days. Thus, there is an urgent need to extend this work to examine patterns of rhythmicity and regularity in BD. Actigraphy research holds great promise to identify a much-needed specific phenotypic marker for BD that will aid in the development of improved detection, treatment, and prevention options.

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Changing gears in the treatment of bipolar disorder through integrated use of electronic devices

Cited by 2 publications

References 5 publications

Fell on Black Days: Analyzing the Song Lyrics of Chris Cornell for Insight into Depression and Suicide

Fell on Black Days: Analyzing the Song Lyrics of Chris Cornell for Insight into Depression and Suicide

Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy

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