Changing ischaemic lesion patterns in adult moyamoya disease

Kim, Jeong‐Min; Lee, Seung‐Hoon; Roh, Jae-Kyu

doi:10.1136/jnnp.2008.145078

Cited by 54 publications

(42 citation statements)

References 17 publications

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“…Vascular imaging with MRA, computed tomography angiography or conventional catheter angiography is essential to demonstrate stenotic or occlusive lesions in the distal internal carotid arteries and the arteries around the circle of Willis. Transcranial doppler ultrasonography provides a noninvasive alternative to evaluate intracranial hemodynamics and large artery stenosis (4)(5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Sudden Onset Monoparesis and Dysarthria in a 5-Year-Old boy: A Case Report

Okhovat

Moeini

2015

Thrita

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Introduction: Moyamoya disease (MD) is a disorder caused by blocked arteries at the base of the brain. As the normal blood vessels narrow and become blocked, a person may suffer a stroke. The MD mainly affects children, although adults may have the condition. This is a rare condition, with a marked prevalence gradient between Asian countries. Case Presentation: We report a 5-year-old boy, who was presented with sudden right hand monoparesis and dysarthria. Conclusions: The patient was investigated with magnetic resonance angiography and diagnosed as MD.

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Section: Discussionmentioning

confidence: 99%

Sudden Onset Monoparesis and Dysarthria in a 5-Year-Old boy: A Case Report

Okhovat

Moeini

2015

Thrita

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“…This is likely due to overall increased secondary MMD burden because all patients with posterior region involvement also had evidence of cortical strokes or WMD in the anterior (frontotemporal) regions. Kim et al 10 found that adult MMD severity, as measured by degree of intracranial arterial involvement on cerebral angiography, increased in patients with ischemic lesions involving the cortical regions and the posterior part of the brain. This finding may be related to later involvement of the posterior cerebral arteries in advanced stages of MMD.…”

Section: Discussionmentioning

confidence: 99%

Neuroradiologic Correlates of Cognitive Impairment in Adult Moyamoya Disease

Mogensen¹,

Karzmark²,

Zeifert³

et al. 2011

AJNR Am J Neuroradiol

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“…10,12 Previous investigations of pediatric and adult patients with MMD have demonstrated that ischemic lesions tend to occur in the watershed area initially and then spread to a wider area involving the posterior part of the brain as the PCA narrows. 5,12 Our data show that steno-occlusive PCA lesions have a significant impact on the severity of ischemia and could be an important landmark for both pediatric and adult patients at high risk for infarctions.…”

Section: Impact Of Posterior Circulation Involvement On Ischemiamentioning

confidence: 99%

“…However, PCAs are often involved after progression of ICA lesions, and the clinical significance of steno-occlusive PCA lesions in MMD has been demonstrated. 4,5,7,[9][10][11][12]15 The clinical characteristics of pediatric patients with MMD are quite different from those of adult patients. Most pediatric patients with MMD develop ischemic complications, and approximately half of adult patients suffer intracranial hemorrhage and half suffer ischemic complications.…”

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confidence: 99%

Assessment of the difference in posterior circulation involvement between pediatric and adult patients with moyamoya disease

Hishikawa¹,

Tokunaga²,

Sugiu³

et al. 2013

JNS

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Object. There is no description of the change in the posterior cerebral artery (PCA) in the diagnostic criteria of moyamoya disease (MMD). However, PCAs are often involved in the clinical setting, and an understanding of the significance of PCA lesions is therefore of great importance when evaluating the disease progression and predicting prognosis. The aim of this study was to assess the difference in posterior circulation involvement in pediatric and adult patients with MMD.Methods. The records of 120 consecutive patients with MMD were reviewed. The clinical manifestations at diagnosis were evaluated on the basis of symptoms and CT and MRI findings. The degree of steno-occlusive internal carotid artery (ICA) lesions and the existence of steno-occlusive PCA lesions were evaluated by observing a total of 240 ICAs and PCAs on angiography. Angiographic correlation between anterior and posterior circulation was assessed in pediatric and adult patients with MMD.Results. Seventeen (26%) of 66 pediatric patients and 18 (33%) of 54 adult patients exhibited steno-occlusive PCA lesions. There was no significant difference in the prevalence of PCA lesions between pediatric and adult patients with MMD (p = 0.36). The prevalence of infarction in pediatric and adult patients with PCA involvement was significantly higher than that in pediatric and adult patients without PCA involvement (p = 0.0003 and p = 0.003, respectively). There was no significant difference in the distribution of infarction areas between pediatric and adult patients with PCA involvement (p = 0.62). On the basis of the staging system used, steno-occlusive lesions in ICAs ipsilateral to PCAs with lesions were in significantly advanced stages compared with lesions in ICAs ipsilateral to PCAs without lesions in both pediatric and adult cases (p < 0.0001 and p = 0.0008, respectively). Pediatric patients had less advanced steno-occlusive lesions in ICAs ipsilateral to PCAs with lesions compared with adults (p < 0.05).Conclusions. The clinical significance of posterior circulation involvement in MMD was similar between pediatric and adult patients. The only significant difference was that less advanced ICA lesions could complicate posterior circulation involvement in pediatric patients.

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Changing ischaemic lesion patterns in adult moyamoya disease

Cited by 54 publications

References 17 publications

Sudden Onset Monoparesis and Dysarthria in a 5-Year-Old boy: A Case Report

Sudden Onset Monoparesis and Dysarthria in a 5-Year-Old boy: A Case Report

Neuroradiologic Correlates of Cognitive Impairment in Adult Moyamoya Disease

Assessment of the difference in posterior circulation involvement between pediatric and adult patients with moyamoya disease

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