By 2031, culturally and linguistically diverse students will represent approximately 55% of students enrolled in United States public schools (National Center for Educational Statistics, 2023). Despite increased ethnic diversity among students, most teachers are White. Consequently, many new teachers report feeling ill-equipped to implement culturally responsive teaching strategies to meet the needs of culturally and linguistically diverse students. To prepare culturally responsive preservice teachers, teacher preparation programs can embed technologies such as mixed-reality simulation paired with explicit instruction and performance feedback to support the preservice teachers’ implementation of culturally responsive teaching strategies. This mixed methods (convergent parallel design) pilot study evaluated how using mixed-reality simulation, explicit teaching, and performance feedback impacts preservice teachers’ knowledge of culturally responsive teaching strategies and self-efficacy. Results indicated that participants increased their knowledge, implementation, and self-efficacy. We discuss the findings and limitations and offer recommendations to improve mixed-reality simulation within teacher preparation programs and recommendations for future research.