Changing paternal age distribution and the human mutation rate in Europe

Modell, Bernadette; Kuliev, Anver

doi:10.1007/bf00197705

Cited by 19 publications

(11 citation statements)

References 13 publications

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“…This practice is particularly common throughout the eastern Mediterranean, North Africa and the Indian subcontinent, and to a lesser extent in parts of South America and Sub-Saharan Africa [13][14][15]. Although it has not been possible to obtain accurate data about its effect on the gene frequencies of the hemoglobin disorders, it undoubtedly has the effect of increasing their frequency in those countries in which it is still widely practiced.…”

Section: Population Genetics and Dynamicsmentioning

confidence: 99%

Hemoglobinopathies Worldwide: Present and Future

Weatherall¹

2008

CMM

118

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The genetic disorders of hemoglobin, the commonest monogenic diseases, occur at some of their highest frequencies in the developing countries, particularly those of Sub-Saharan Africa and Asia. Although progress towards their control and management continues to be made, the prospects for curing them, apart from marrow transplantation, remain uncertain. In many countries expertise and facilities for their control are extremely limited. Although a great deal can be done to help the situation by developing further North/South and South/South partnerships for disseminating better practice, the major problem for the future lies in the unwillingness of governments and international health agencies to accept that the hemoglobinopathies represent a health burden comparative to that of communicable and other major diseases. However, preliminary analyses suggest that, at least in the case of Asia, this may not be true. Further work of this type, together with more detailed frequency and economic data, is required to provide solid evidence for the health burden posed by the hemoglobin disorders, particularly in the developing world. Unless this is done, the increasingly large populations of patients with these diseases will continue to be neglected.

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Section: Population Genetics and Dynamicsmentioning

confidence: 99%

Hemoglobinopathies Worldwide: Present and Future

Weatherall¹

2008

CMM

118

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“…The rate may also have been increased by man-made chemicals in the recent environment. O n the other hand, elimination of mutagens in decaying food or possible decrease of the average paternal age of reproduction (Model1 and Kuliev, 1990) may have lowered the rate in some modern societies. However, the rough agreement between the overall mutation rate from direct measurements (Nee1 et al, 1986) and from the study of primate evolution rates argues against any large recent change, although the numbers are too small and the assumptions too uncertain for any precision.…”

Section: Possible Implicationsmentioning

confidence: 99%

A molecular approach to estimating the human deleterious mutation rate

1993

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We propose a method of measuring the human genomic deleterious mutation rate based on comparison of the rate of evolution per nucleotide per generation of neutral sequences, microN, with the overall rate of evolution of unique sequence DNA, microO. Data on microN, which are based on pseudogenes, permit an estimate of the total zygotic (twice the genomic) mutation rate, UT = 2 microNn = 2(2 x 10(-8)(3 x 10(9)) approximately 10(2), where n is the number of nucleotides per genome. Data on microO can be obtained by comparison of representative samples of relatively short homologous sequences from the genomes of Homo and a related species. The fraction of the genome that is controlled by negative selection is fS = (microN - microO)/microN and the deleterious zygotic mutation rate, the expected number of new deleterious alleles carried by a zygote, is US = UTfS. If fS > 0.01, US > 1, which would have important implications for human genetics and evolutionary biology.

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“…People who have greater access to medical knowledge and services are more likely to be aware of this medical belief and act accordingly. This is supported by the observation Downloaded by [University of Regina] at 19:06 16 November 2014 that reduction of parental age occurs as a result of family planning (Modell & Kuliev, 1990). When people are told through family planning information that they should have babies when the woman is young, they tend to follow this advice.…”

Section: Following Belief In Biological Time Clockmentioning

confidence: 89%

“…Factors in paternal physiology tend to be given less attention. In 1991 Medline had no search category for "paternal age 35 and over" corresponding to the search category "maternal age 35 and over," despite one Medline source where authors suggest "that the human mutation rate increases with paternal age" (Modell & Kuliev, 1990) and another suggestion that the rate of chromosomal abnormalities is probably doubled if the father's age is over 55 (Taysi, 1988). In Medline from 1985 to 1999 sources that highlight maternal age outnumbered those highlighting paternal age by approximately 10-to 20-fold.…”

Section: Downloaded By [University Of Regina] At 19:06 16 November 2014mentioning

confidence: 99%

Questioning the Construction of Maternal Age as a Fertility Problem

Hanson

2003

Health Care for Women International

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The belief that fertility problems derive from maternal age, increasing markedly at 35, reflects social constructions of biology in developed nations. These constructions perpetuate a negative view of female aging. However, research since 1985 can be interpreted to suggest that there is no, or minimal, association between maternal age and problems associated with fertility. Differences in problems between pre- and postmaternal age 35 fertility can be explained by social conditions occurring with fertility, notably, parenting decisions, physical problems with the male and the potential child, and medical intervention. Once we look at fertility as a relationship among the woman, the man, and the potential child, rather than the woman only, we can see these factors. These components suggest that maternal age may be related only tangentially to successful fertility.

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Changing paternal age distribution and the human mutation rate in Europe

Cited by 19 publications

References 13 publications

Hemoglobinopathies Worldwide: Present and Future

Hemoglobinopathies Worldwide: Present and Future

A molecular approach to estimating the human deleterious mutation rate

Questioning the Construction of Maternal Age as a Fertility Problem

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