Changing patterns of gastric cancer mortality in Spain

Palmeiro, R.; Senra, Ana; Garcia-Blanco, P.; Millan, J

doi:10.1016/0304-3835(88)90245-5

Cited by 6 publications

(7 citation statements)

References 6 publications

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“…The mean age was 52 years (range: 32-80). Reasons for exclusion being: diagnosis not confirmed by histopathology [6], advanced stage at time of diagnosis [3], or patient’s refusal [2]. We included women who had been operated on recently, women whose disease was in prolonged clinical remission, and women with just detected active recurrence that had not yet been treated with chemotherapy/hormotherapy/inmmu-notherapy/radiotherapy.…”

Section: Methodsmentioning

confidence: 99%

“…In Spain, incidence of breast cancer increased is 2.26 times the mortality from this tumour [1] and mortality from breast cancer increased 122% in absolute terms (62% adjusted rate) from 1961 to 1980 [2]. It are look at the changes in Spain during this period in comparison with the preceding years it shows that socioeconomic level increased significantly, and so did food availability and consumption [3]. During the same period there was a clear decrease in mortality from stomach cancer [4].…”

Section: Introductionmentioning

confidence: 99%

“…Women who became obese as adults, the degree of obesity was inversely related with age at menarche: the greater the Quetelet index in adulthood, the younger the age at menarche [7]. This finding suggests that early menarche is not a primary risk factor for breast cancer, but is rather a consequence of the increasing socioeconomic level in Spain and the diet [3]. The epidemiological evidence of an association between dietary fat and the development of breast cancer is strong and is supported by numerous animal models.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

López-Sáez¹,

Martinez-Rubio²,

Alvarez³

et al. 2008

TOCCJ

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Background: There are indications that mortality in breast cancer is related with dietary factors, but no study has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain. Patients and Methods:We carried out a simple a case-control study comparing 204 women with breast cancer (96 premenopausal and 108 postmenopausal women) and 250 healthy control subjects. The predictive variables were basal glycaemia, insulin, glycosylated haemoglobin (HbA1c), C-peptide, insulin-like growth factor-I (IGF-I), total cholesterol, triglycerides, high density lipoprotein-c (HDL-C), low density lipoprotein-c (LDL-C), selenium and Quetelet index (BMI). Results:The metabolic profile differed between pre-and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women. The differences between healthy subjects and breast cancer patients were clearly significant. Conclusions:Our findings have several potential practical applications in the early detection of breast cancer, especially in premenopausal women; in primary prevention; and in the development of a mathematical model of breast carcinogenesis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

López-Sáez¹,

Martinez-Rubio²,

Alvarez³

et al. 2008

TOCCJ

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“…Corella et al and Palmeiro and colleagues reported that gastric cancer incidence is higher in mountainous sites than coast sites in Spain [10,23]. Because of the altitude and the long and cold winters, vegetable and fruit production and transport is rare in East Anatolia, also socio-economical status of this region is lower than the other regions of Turkey.…”

Section: Discussionmentioning

confidence: 98%

Dietary Habits, Demographical, and Socio-economical Risk Factors of the Newly Diagnosed Gastric Cancers in the Eastern Anatolia Region of Turkey: An Endemic Upper Gastrointestinal Cancer Region

2008

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The Eastern Anatolia Region of Turkey is an endemic upper gastrointestinal (esophageal and gastric) cancer region, and the incidence of these cancers are still increasing in the region. We investigated demographic features, dietary habits, and some possible etiologic factors for this high prevalence. Special attention was given to the relationship between consumption of boiled yellow butter and the occurrence of gastric cancer. Age, sex, residential area, socio-economical status, educational status, vegetable and fruit consumption, alcohol and tobacco use, tea consumption, boiled butter usage, cooking and storage methods of the patients with gastric cancer and controls were investigated in East Anatolian Regional Erzurum State Hospital. Helicobacter pylori infection for gastric cancer risk was not studied. Fruit, yellow-green vegetables, boiled butter, and breads baked by animal manure consumptions and no refrigeration are found to be statistically significant etiologic factors for gastric carcinogenesis. Dietary habits might be risk factors for gastric carcinogenesis among East Anatolian population. Some regional differences in food processing and preparation also seem to play a role in gastric carcinogenesis.

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“…Mortality due to gastric cancer in Spain has decreased markedly since the period from 1960 to 1965, but remains high in some mountain locations [1]. In the southern Atlantic province of Cadiz, coastal towns such as Barbate have an adjusted mortality rate of 10/100.000 inhabitants, whereas towns such as Ubrique, located in the mountainous region 30 kilometers inland, have an adjusted mortality rate of 20/100.000 [2].…”

Section: Introductionmentioning

confidence: 99%

Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection

López-Sáez

Gómez-Biondi

Santamaría-Rodriguez

et al. 2010

J Exp Clin Cancer Res

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Background & AimsIn the province of Cadiz (Spain), the adjusted mortality rate for gastric cancer in the coastal town of Barbate is 10/100.000 inhabitants, whereas in the inland town of Ubrique, the rate is twice as high. The rate of Helicobacter pylori (H. pylori) infection (H. pylori antibodies) in the normal population was 54% in Ubrique, but only 32% in Barbate. In the two decades since its original discovery, p53 has found a singularly prominent place in our understanding of human gastric cancer and H. pylori cause accumulation of reactive oxygen species in the mucosa compartment. This study was designed to compare serum levels of p53 in a population characterized by high mortality due to stomach cancer and a high prevalence of H. pylori infection and another population in which mortality from this cause and the prevalence of H. pylori infection are low.Materials and methods319 subjects from the low mortality population and 308 from the high mortality population were studied, as were 71 patients with stomach cancer. We measured serum immunoglobulin G antibody to H. pylori and serum mutant p53 protein and ceruloplasmin.ResultsThe difference between the two populations in the prevalence of H. pylori infection was significant (p < 0.001). Of the seropositive, 81% had elevated values of mutant p53, in comparison with 11% of the seronegative (p < 0.0001). Serum concentration of ceruloplasmin was significantly higher in seropositive with elevated mutant p53 protein than in seronegative with normal levels of p53 (p < 0.05).ConclusionsThere is a significant association between infection with H. pylori, elevated titers of H. pylori antibodies, and positivity for serum mutant p53 protein. Such information can significantly increase our basic knowledge in molecular pathology of gastric cancer and protection against H. pylori infection.

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Changing patterns of gastric cancer mortality in Spain

Cited by 6 publications

References 6 publications

Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain

Dietary Habits, Demographical, and Socio-economical Risk Factors of the Newly Diagnosed Gastric Cancers in the Eastern Anatolia Region of Turkey: An Endemic Upper Gastrointestinal Cancer Region

Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection

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