Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

Frimodt‐Møller, Niels; Bak, A. Leth; Stenderup, A; Zachariae, H; H, Afzelius

doi:10.1128/aac.11.3.388

Cited by 41 publications

(11 citation statements)

References 22 publications

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“…The high percentage of tetracycline-resistant strains in the B. fragilis group could be partly considered as a long-term consequence of the wide clinical use of tetracycline in therapy, particularly the prolonged administration of the antibiotic on a large scale in acne treatment (14). The prescription of tetracycline has decreased considerably in France in recent years.…”

Section: Discussionmentioning

confidence: 99%

Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance

Privitera¹,

Fayolle²,

Sébald³

1981

Antimicrob Agents Chemother

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The transferability of plasmid-mediated tetracycline, erythromycin, and clindamycin resistance was studied in 63 clinical isolates of the Bacteroides fragilis group. Of 48 strains which were tetracycline resistant (Tcr), the regulation of both the expression of Tcr and its transferability was shown to be under inducible control by tetracycline. In 29 of the strains, Tcr was transferable; in the majority of these (26 strains), transferability was inducible (Trai) and it was constitutive (Trac) in only 3 strains. All four possible phenotypes were found (Tci Trai, Tci Trac, Tcc Trai, and Tcc Trac), which indicates independent control of both Tcr expression and its transferability. Resistance to erythromycin and clindamycin was cotransferred with Tcr in 14 of the 48 Tcr strains and transferred independently of Tcr in only 1 strain.

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Section: Discussionmentioning

confidence: 99%

Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance

Privitera¹,

Fayolle²,

Sébald³

1981

Antimicrob Agents Chemother

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“…Several studies have clearly demonstrated that the administration of even a single antibiotic can select for MDR strains during human or veterinary clinical therapy (11,23,34). In the current study, MDR was observed in most WW and RWD isolates, possibly due to long-term exposure of the microorganisms to high concentrations of OTC.…”

Section: Discussionmentioning

confidence: 99%

“…To gain a comprehensive understanding of this relationship, we isolated bacterial strains from wastewater (WW) and river water downstream (RWD) and river water upstream (RWU) samples using nonselective culture media. Previously, it was shown that long-term administration of a single antibiotic can lead to MDR, a phenomenon that has been observed in bacteria obtained from the urinary tract, intestine, and other niches in both clinical therapy and livestock raising (11,23,34). Thus, the combination of long-term treatment and discharge of antibiotic production wastewater might contribute to MDR in environmental bacteria in this specific ecosystem.…”

mentioning

confidence: 99%

Antibiotic Resistance Characteristics of Environmental Bacteria from an Oxytetracycline Production Wastewater Treatment Plant and the Receiving River

Dong

Zhang

et al. 2010

Appl Environ Microbiol

265

146

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We characterized the bacterial populations in surface water receiving effluent from an oxytetracycline (OTC) production plant. Additional sampling sites included the receiving river water 5 km upstream and 20 km downstream from the discharge point. High levels of OTC were found in the wastewater (WW), and the antibiotic was still detectable in river water downstream (RWD), with undetectable levels in river water upstream (RWU). A total of 341 bacterial strains were isolated using nonselective media, with the majority being identified as Gammaproteobacteria. The MICs were determined for 10 antibiotics representing seven different classes of antibiotics, and the corresponding values were significantly higher for the WW and RWD isolates than for the RWU isolates. Almost all bacteria (97%) from the WW and RWD samples demonstrated multidrug-resistant (MDR) phenotypes, while in RWU samples, these were less frequent (28%). The WW and RWD isolates were analyzed for the presence of 23 tetracycline (tet) resistance genes. The majority of isolates (94.2% and 95.4% in WW and RWD, respectively) harbored the corresponding genes, with tet(A) being the most common (67.0%), followed by tet(W), tet(C), tet(J), tet(L), tet(D), tet(Y), and tet(K) (in the range between 21.0% and 40.6%). Class I integrons were detected in the majority of WW and RWD isolates (97.4% and 86.2%, respectively) but were not associated with the tet genes. We hypothesize that the strong selective pressure imposed by a high concentration of OTC contributes to the wide dissemination of tetracycline resistance genes and other antibiotic resistance genes, possibly through mobile genetic elements.

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“…We examined ampicillin, sulfonamide, tetracycline, and ciprofloxacin exposures in all three models because of possible genetically linked resistance caused by plasmid 35,36 and transposon 37 transmission of multiple resistance factors, and to account for possible collinearity of antibiotic exposures.…”

Section: Study Sitementioning

confidence: 99%

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

Kalter¹,

Gilman²,

Moulton³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. Few studies have examined the influence of individual-, household-, and community-scale risk factors on carriage of resistant commensal bacteria. We determined children's medical, agricultural, and environmental exposures by household, pharmacy, and health facility surveys and Escherichia coli cultures of children, mothers' hands, household animals, and market chickens in Peru. Among 522 children with a positive stool culture, by log-binomial regression, using "any antibiotic" and 1-14 (versus 0) sulfa doses in the past 3 months increased children's risk, respectively, for ampicillin-and sulfamethoxazole-resistant E. coli carriage ( P = 0.01-0.02). Each household member taking "any antibiotic" increased children's risk for sulfamethoxazole-and multidrug-resistant E. coli carriage ( P < 0.0001). Residence in a zone where a larger proportion of households served home-raised chicken (as contrasted with intensively antibiotic-raised market chicken) protected against carrying E. coli resistant to all drugs ( P = 0.0004-0.04). Environmental contamination with drug-resistant bacteria appeared to significantly contribute to children's carriage of antibiotic-resistant E. coli .

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Changing Patterns of Plasmid-Mediated Drug Resistance During Tetracycline Therapy

Cited by 41 publications

References 22 publications

Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance

Resistance to tetracycline, erythromycin, and clindamycin in the Bacteroides fragilis group: inducible versus constitutive tetracycline resistance

Antibiotic Resistance Characteristics of Environmental Bacteria from an Oxytetracycline Production Wastewater Treatment Plant and the Receiving River

Risk Factors for Antibiotic-Resistant Escherichia coli Carriage in Young Children in Peru: Community-Based Cross-Sectional Prevalence Study

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