Changing patterns of postoperative nausea and vomiting prophylaxis drug use in an academic anesthesia practice

Wax, David B.; Doshi, Ankur M.; Bodian, Carol; Krol, Marina; Reich, David L.

doi:10.1016/j.jclinane.2007.02.008

Cited by 14 publications

(18 citation statements)

References 8 publications

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“…All of the 70 publications included are observational studies based on routinely collected health data, which included health insurance or hospital records. Thus, no RCTs were found for the defined search period.…”

Section: Resultsmentioning

confidence: 99%

Do drug‐related safety warnings have the expected impact on drug therapy? A systematic review

Georgi

Lämmel

Datzmann

et al. 2020

Pharmacoepidemiology and Drug

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Purpose The need for drug‐related safety warnings is undisputed, and their impact should also be evaluated. This systematic review investigates and assesses the impact of safety warnings on drug therapy. Methods Studies published in English between January 1998 and December 2018 were searched in EMBASE and MEDLINE, complemented by manual search. Randomised controlled trials, cohort studies with a before/after component, and case‐control studies were included, selected to predefined criteria, and assessed for their reporting and methodological quality. Results Out of 7454 references identified, 72 studies were included. A total of 28/72 (39%) studies described the impact of safety warnings on drug therapy as being effective, whereas 12/72 (17%) studies did not. Further, 26/72 (36%) studies described a partial implementation of the warnings (one part of the warning had an impact on drug therapy and another did not). Unintended effects were investigated in 6/72 (8%) studies. While 34 (47%) studies examined safety warnings on psychotropic drugs using an interrupted time series (ITS) design (53%), a before/after (26%), and a time series design (21%), 38 (53%) studied other substances using an ITS design (34%), a before/after (40%), and a time series design (26%). The proportion of an effective impact on drug therapy was lower in the “psychotropic drugs” group (23%) than in the “others” group (53%). Conclusion Drug‐related safety warnings induce intended and unintended effects. The included studies are of broadly varying methodological quality. To better compare their effectiveness, studies should be conducted using standardised procedures.

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Section: Resultsmentioning

confidence: 99%

Do drug‐related safety warnings have the expected impact on drug therapy? A systematic review

Georgi

Lämmel

Datzmann

et al. 2020

Pharmacoepidemiology and Drug

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“…The response to these communications has varied considerably. A study of droperidol saw a significant decrease of use following the December 2001 black box warning, accompanied by an even greater increase in use of ondansetron, a known substitute (45). Studies examining the use of LABAs among patients with asthma suggested infrequent controller use (e.g., inhaled corticosteroids) among individuals prior to their receiving a LABA, and neither investigation suggested large changes in rates of controller use following the FDA warnings (46,47).…”

Section: Resultsmentioning

confidence: 99%

Impact of FDA Drug Risk Communications on Health Care Utilization and Health Behaviors

et al. 2012

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Objective To review literature on the impact of FDA drug risk communications on medication utilization, health care services use, and health outcomes. Data Sources The authors searched MEDLINE and the Web of Science for manuscripts published between January 1990 and November 2010 that included terms related to drug utilization, the FDA, and advisories or warnings. We manually searched bibliographies and works citing selected articles and consulted with experts to guide study selection. Study Selection Studies were included if they involved an empirical analysis evaluating the impact of an FDA risk communication. Data Extraction We extracted the drug(s) analyzed, relevant FDA communication(s), data source, analytical method, and main outcome(s) assessed. Results Of the 1432 records screened, 49 studies were included. These studies covered sixteen medicines or therapeutic classes; one-third examined communications regarding antidepressants. Most used medical or pharmacy claims and few rigorously examined patient-provider communication, decision-making or risk perceptions. Advisories recommending increased clinical or laboratory monitoring generally led to decreased drug use, but only transient and modestly increased monitoring. Communications targeting specific subpopulations often spilled over to other groups. Repeated or sequential advisories tended to have larger but delayed effects and decreased incident more than prevalent use. Drug-specific warnings were associated with particularly large decreases in utilization, though the magnitude of substitution within therapeutic classes varied across clinical contexts. Conclusions While some FDA drug risk communications had immediate, strong impacts, many had either delayed or no impact on health care utilization or health behaviors. These data demonstrate the complexity of using risk communication to improve the quality and safety of prescription drug use, and suggest the importance of continued assessments of the effect of future advisories and label changes. Identifying factors that are associated with rapid and sustained responses to risk communications will be important for informing future risk communication efforts.

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“…After many years of extensive use for prophylaxis of PONV, droperidol’s usage among anesthesiologists drastically declined after 2001, when the FDA issued a black box warning of a risk of TdP (8–10). Use of 5HT 3 ‐receptor agonists, such as ondansetron, has risen commensurately.…”

Section: Discussionmentioning

confidence: 99%

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children

Mehta

Sanatani

Whyte

2010

Pediatric Anesthesia

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Changing patterns of postoperative nausea and vomiting prophylaxis drug use in an academic anesthesia practice

Cited by 14 publications

References 8 publications

Do drug‐related safety warnings have the expected impact on drug therapy? A systematic review

Do drug‐related safety warnings have the expected impact on drug therapy? A systematic review

Impact of FDA Drug Risk Communications on Health Care Utilization and Health Behaviors

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children

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