Changing patterns of prevalence in Opisthorchis viverrini sensu lato infection in children and adolescents in northeast Thailand

Khuntikeo, Narong; Sithithaworn, Paiboon; Loilom, Watcharin; Namwat, Nisana; Yongvanit, Puangrat; Thinkhamrop, Bandit; Kiatsopit, Nadda; Andrews, Ross H.; Petney, Trevor N.

doi:10.1016/j.actatropica.2016.10.017

Cited by 17 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average temperature was 27.7 °C (16.0 °C-39.9 °C) with an annual rainfall of 1031.4 mm [ 15 ]. Factors associated with the tropical environment in this area (especially education, socio-cultural factors, economic factors, climate, land use, rivers, and rainfall) affect the prevalence of intestinal parasite infection (including that of S. stercoralis and O. viverrini ) [ 16 , 17 ]. The Mueang Khon Kaen District was selected as the study site because it has a higher prevalence of strongyloidiasis than any other district in Khon Kaen [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors

et al. 2018

View full text Add to dashboard Cite

BackgroundTwo important helminths, Strongyloides stercoralis (an intestinal roundworm) and Opisthorchis viverrini (a liver fluke), are endemic in northeast Thailand. There have been national campaigns in place aimed at the control and eradication of soil-transmitted helminthiasis and opisthorchiasis in Thailand for several decades. However, these helminths still exist and raise concerns regarding public health. This study aimed to evaluate the current prevalence of S. stercoralis and O. viverrini infections in rural communities in northeast Thailand. The data from this study will be useful to improve strategies for future helminth prevention and control.MethodsA cross-sectional study was conducted from December 2016 to June 2017 in Mueang Khon Kaen district in Khon Kaen, Thailand. The participants were selected using a simple random sampling method. Demographic data were collected using a questionnaire. Stool samples were collected and processed using agar plate culture to determine the presence of S. stercoralis infection and an in-house formalin-ethyl acetate concentration technique to determine the presence of O. viverrini and other intestinal parasite infections (IPIs).ResultsIn total, 602 persons were enrolled. However, only 526 were analyzed for S. stercoralis and 387 for O. viverrini risk factors. The overall prevalence of S. stercoralis infection was 23.0% (95% confidence interval [95%CI]: 19.4 to 26.6). The prevalence of O. viverrini infection and IPIs other than S. stercoralis was 20.4% (95%CI: 16.5 to 24.8). The prevalence of O. viverrini infection was 19.4% (95%CI: 15.6 to 23.7). Male sex was significantly associated with S. stercoralis infection [Adjusted Odds Ratio (aOR) 4.0; 95%CI: 2.5 to 6.2; P-value < 0.001]. Males were significantly more likely to be infected with O. viverrini and other IPIs (aOR 4.1; 95%CI: 2.3 to 7.2, P-value < 0.001).ConclusionsThis study demonstrated that the updated prevalence of intestinal parasite infections is still high in rural communities in northeast Thailand, especially that of strongyloidiasis and opisthorchiasis.

show abstract

Section: Methodsmentioning

confidence: 99%

Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Chronic infection caused by the Southeast Asian liver fl uke (Opisthorchis viverrini) is a critical risk factor for the development of the bile duct cancer cholangiocarcinoma (CCA), what is a major health concern in South-East Asia (Thailand, Laos People's Democratic Republic, Cambodia and central Vietnam) Aunpromma et al, 2012;Miyamoto et al, 2014;Kaewpitoon et al, 2015;Khuntikeo et al, 2016). In Thailand at least 6 million people are estimated to be currently infected (Andrews et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

et al. 2017

View full text Add to dashboard Cite

SummaryAn integrated epidemiological study of Opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs (dogs and cats) and intermediate hosts (cyprinid fi sh) was carried out in the vicinity of Huay Luang dam, Udon Thani province, in the north east of Thailand. The survey was conducted from June 2014 to July 2016 in three sub-districts. Fecal samples were collected from 5,347 participants in 22 villages and the overall prevalence of O. viverrini was found to be 31.5 %. Risk factors for liver fl uke infection were determined from questionnaires analysis which sought demographic data and information about the eating behaviors of the participants. The behavior of raw fi sh consumption correlated signifi cantly with parasitation in the studied areas. The risk factors for O. viverrini infection in humans were associated signifi cantly with age, education, and habitation within a two kilometer range from nearby water and food sources. Questionnaires showed that the drug treatments were not always appropriate. The stools of domestic dogs (n = 468) and cats (n = 262) collected for parasitological analysis and results showed that the zoonotic role of dogs should not be underestimated as has been done previously/in past. The incidence of O. viverrini metacercariae in four cyprinid fi shes Barbonymus gonionotus (n = 124), Cyclocheilichthys repasson (n = 843), Hampala dispar (n = 276) and Henicorhynchus siamensis n = 946), were determined and overall values ranged from 2.4 % to 23.1 %. There was a seasonal variation in metacercariae intensity which ranged from 1 -125 metacercariae per fi sh. The study concluded that transmission ecology should be taken into consideration in developing of control strategies against opisthorchiasis.

show abstract

“… 1 It is reported that up to 20,000 new cases with liver fluke–induced cholangiocarcinoma (CCA) are detected annually in Thailand alone. 2 Khuntikeo et al 3 also reported that the O. viverrini infection landscape is beginning to shift among school children as a result of school education and community control programmes in Thailand. They predicted that CCA prevalence will decline within the next decade.…”

mentioning

confidence: 99%

Characterisation of the Urinary Metabolic Profile of Liver Fluke-Associated Cholangiocarcinoma

Alsaleh

Sithithaworn

Khuntikeo

et al. 2019

Journal of Clinical and Experimental Hepatology

Self Cite

View full text Add to dashboard Cite

Background: Human infection with Opisthorchis viverrini, a carcinogenic liver fluke inhabiting the biliary tree, is endemic in Southeast Asia. Chronic infection is associated with a fatal complication, cholangiocarcinoma (CCA), a late-presenting and aggressive malignancy. Currently, annual mortality rates from CCA mirror trends in incidence, due in part to limited availability of efficient prognostic and early diagnostic biomarkers. With ability to detect thousands of urinary metabolites using metabonomics, the urine metabolome holds great potential in providing an insight into system-level alterations in carcinogenesis and in identifying metabolic markers altered in response to disturbed homoeostasis. Methods: Global molecular profiling using reversed-phase ultraperformance liquid chromatography mass spectrometry was utilised to acquire the urinary spectral profile of 137 Thai subjects (48 at high risk of infection, 41 with O. viverrini infection, 34 periportal fibrosis and 14 CCA) from Khon Kaen, Thailand. Results: Multivariate statistical analysis identified perturbation in several molecular classes related to purine metabolism and lipid metabolism in the CCA urine metabolome. These markers mainly reflect changes in energy metabolism to support proliferation (increased fatty acid oxidation and purine recycling), DNA methylation and hepatic injury. Conclusions: Several metabolites of biological interest were discovered from this proof-of-principle dataset. Augmenting these findings is essential to accelerate the development of urinary metabolic markers in CCA.

show abstract

Changing patterns of prevalence in Opisthorchis viverrini sensu lato infection in children and adolescents in northeast Thailand

Cited by 17 publications

References 24 publications

Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors

Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors

Epidemiology of Opisthorchis viverrini in an endemic area of Thailand, an integrative approach

Characterisation of the Urinary Metabolic Profile of Liver Fluke-Associated Cholangiocarcinoma

Contact Info

Product

Resources

About