Changing Spectrum of Squamous Cell Abnormalities Observed on Papanicolaou Smears in Mubarak Al-Kabeer Hospital, Kuwait, over a 13-Year Period

Kapila, Kusum; George, Sara S.; Al-Shaheen, Azza; Al-Ottibi, M.S.; Pathan, Shahed K.; Sheikh, Zafar A.; Haji, Bahiyah E.; Mallik, Mrinmay K.; Das, Dilip K.; Francis, Issam M.

doi:10.1159/000092986

Cited by 35 publications

(31 citation statements)

References 29 publications

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“…Similar studies have shown the percentage of inadequate smears have ranged from 0.2% to 13.94%. [14][15][16] The proportion of satisfactory samples received was impressively high as in our institute cervical smears were taken by trained gynecologists and then send to department of pathology for analysis, therefore, reducing costs and inconvenience of the patients.…”

Section: Discussionmentioning

confidence: 99%

Cytomorphological evaluation of squamous cell abnormalities observed on cervical smears in government medical college, Jabalpur, India: a five year study

2016

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INTRODUCTIONCervical cancer is the fourth most common cancer in women and the seventh overall, with an estimated 528,000 new cases every year. Cancer cervix is the most common cancer in women in several less developed countries, and now the second most common cancer in India. Almost 70% of the global burden of cervical cancer is in areas with lower levels of development, and more than one fifth of all new cases are diagnosed in ABSTRACT Background: Cervical cancer is the fourth most common cancer affecting women worldwide, the most common cancer in women in several less developed countries, and now the second most common cancer in India. Cervical cytology by papanicolaou (PAP) smear test is an effective tool for detecting abnormal cytology in early stages, thus allowing early detection and treatment. The PAP smear is extremely important for detecting premalignant and malignant conditions of cervix. The study was conducted to determine; (1) Cytomorphologic incidence of various lesions of uterine cervix; (2) Categorization of detected lesions according to Bethesda system; (3) Determination of epithelial abnormalities by cervical cytology. Methods: The settings and design of this study is a hospital based prospective study from a tertiary care centre in Central India. A total of 5813 conventional pap smear tests collected from January 2010 and December 2014 were analyzed. All patients attending outpatient department of obstetrics and gynecology for complaints of abnormal cervical discharge, dyspareunia, inter-menstrual bleeding, post-coital bleeding and lower abdominal pain were included. Various cervical pap screening camps were also done during this period. Smears were fixed and stained with hematoxylin & eosin (H&E) and papanicolaou stain were done. Results: The overall frequency of normal, inadequate, inflammatory, and abnormal smears was 11.86%, 5.73%, 74.98% and 13.2% respectively. Atypical squamous cell carcinoma of undermined significance (ASCUS) was seen in 3.61%, squamous intraepithelial lesion (SIL) was seen in 5.36%, low grade squamous intraepithelial lesion (LSIL) was seen in 2.59% while high grade squamous intraepithelial lesion (HSIL) was seen in 2.77%. Invasive carcinoma was seen in 3.69%. The premalignant epithelial abnormalities like ASCUS, LSIL and HSIL were found to be highest in the age group of 31-50 years in our study, which correlated well with other similar studies. Conclusions: Hence we should advocate regular cervical cytology (PAP) smear study, which can help to treat cervix lesions early before the progress into cervical cancer. Early detection is the only key to saving a woman's life as the later the abnormalities are discovered; mortality, morbidity and treatment cost all increase.

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Section: Discussionmentioning

confidence: 99%

Cytomorphological evaluation of squamous cell abnormalities observed on cervical smears in government medical college, Jabalpur, India: a five year study

2016

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“…In a study conducted by Urmila Banik et al [3] in Bangla Desh in 2010 they found ,ASCUS -0.18 %, AGC-0.12%, L SIL-6.36 % ,H SIL-1.18 % , and malignancy -0.35 %. According to another study in Brazil [10] on 18,22,441 pap smears in 5 years, L SIL was found in the age group of 15-30 years, high grade lesions including cancer cervix were found in women aged 40 years and above. According to our study ASCUS was found in 0.19%, L SIL was found in 0.96 % in the age group of 35-39.…”

Section: Discussionmentioning

confidence: 93%

Uterine Cervical Smear Patterns In Females Attending A Teaching Hospital In Rural Eastern Uttar Pradesh, INDIA.

Bhattacharya¹,

Agarwal²,

Dwivedi³

et al. 2016

IOSR

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“…Cytological diagnosis in relation to age. Arabia, and 6.8% in New Delhi India respectively [16] [17] [18]. The worldwide range of positive cytology from the conventional Pap smear is 10% [19].…”

Section: Discussionmentioning

confidence: 99%

Cervical Cytology: A Review of 597 Cases in a Tertiary Health Centre in Nigeria

Singh¹,

Nnadi²,

Anas³

et al. 2018

CRCM

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Background: Cervical cancer is the most common gynaecological cancer among women in the developing countries. It is preventable by early detection and treatment of the precursor lesions. Cervical cytology became the standard screening test for cervical cancer and premalignant lesions with the introduction of the Papanicolau (Pap) smear. Aim: to determine the uptake, indications and results of cervical cytology in a tertiary health center in Nigeria. Materials and Methods: a 5-year descriptive study of the results of cervical cytology among women who attended the gynaecological outpatient clinic of the Hospital. Results: a total of 597 cases of cervical Pap smears were received at the histopathology department during the study period out of which 20 (3.4%) were inadequate for cytological evaluation. The patients age ranged from 15 to 80 (mean 38.8 SD = 11.4) years. The average annual uptake of the Cervical smear was 9.3% of the total number of patients seen in the gynaecological clinic during the study period and the main indications were routine medical check-up, 256 (42.9%) and cervicitis 76 (12.7%). About 398 (66.7%) were normal smears while 152 (26.3%) were abnormal. Non-specific inflammatory changes were present in 113 (74.3%) cases. Cytology was positive for intraepithelial lesions in 6.8% (39/577) cases. Eighteen percent (7/39) of them were high-grade lesions while squamous cell carcinoma was detected in 12.8% (5/39) cases. Conclusion: the uptake of cervical cytology of 8.7% is low and the main indication was routine check up. Premalignant lesions were detected in 6.8% of cases.

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Changing Spectrum of Squamous Cell Abnormalities Observed on Papanicolaou Smears in Mubarak Al-Kabeer Hospital, Kuwait, over a 13-Year Period

Cited by 35 publications

References 29 publications

Cytomorphological evaluation of squamous cell abnormalities observed on cervical smears in government medical college, Jabalpur, India: a five year study

Cytomorphological evaluation of squamous cell abnormalities observed on cervical smears in government medical college, Jabalpur, India: a five year study

Uterine Cervical Smear Patterns In Females Attending A Teaching Hospital In Rural Eastern Uttar Pradesh, INDIA.

Cervical Cytology: A Review of 597 Cases in a Tertiary Health Centre in Nigeria

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