“…The mainstay emergency room management of sicklecell-associated priapism incorporates analgesia, hydra tion, alkalization, oxygenation, and hypertransfusion of packed red blood cells [6], Rapid transfusion dilutes the percentage of sickle hemoglobin in circulation and sup presses the bone marrow release of additional abnormal red cells, thereby increasing oxygen delivery to the corpo ra [10], Additional conservative measures that have been reported in the literature include ice packs, hot soaks, ene mas, transrectal diathermy, estrogens, hyperbaric oxygen, radiation, anticoagulation, fibrinolytic therapy, vasodila tors, antimuscarinics, anxiolytics, spinal anesthesia with hypotension, and erythrocytophoresis [2,3,11], Partial exchange transfusion to reduce hemoglobin S to 30% or less has been recommended when ischemic priapism per sists beyond 24 h [12], Partial exchange transfusion may be associated with severe neurologic complications, possi bly due to changes in blood viscosity and cerebral blood flow or coexisting coagulation abnormalities aggravated by release of reperfusion metabolites from the corpora [9], Conservative measures are most effective in the pediatric population [2], When these measures fail, invasive management may include aspiration and saline irrigation of the corpora (with or without adrenergic drugs) and shunt procedures from the corpus cavemosum to the glans penis, corpus spongiosum or saphenous vein [13], Unfortunately, sickle cell priapism is prone to recurrence following these proce dures [2], Success with hormonal manipulation to prevent recurrent episodes of priapism in sickle cell patients using diethylstilbestrol and gonadotropin-releasing hormone analogues (leuprolide and goserelin acetates) has been reported recently [14,15]. Success with diethylstilbestrol was achieved in 9 of 11 patients, but priapism recurred in several.…”