Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum

Wong, Kelly L. L.; Nair, Aditya; Augustine, George J

doi:10.3389/fncir.2021.658228

Cited by 17 publications

(17 citation statements)

References 200 publications

(400 reference statements)

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“…The claustrum is an irregularly shaped sheet of neurons located in the basolateral forebrain of the mammalian brain. It is thought to be involved in four main functions: regulation of sleep, consciousness, attention and salience, and memory ( Mathur, 2014 ; Jackson et al, 2020 ; Smith et al, 2020 ; Wong et al, 2021 ). This notion is supported by the dense connectivity of the claustrum with other cortical regions ( Smith and Alloway, 2010 ; Patzke et al, 2014 ; Torgerson et al, 2015 ; Kitanishi and Matsuo, 2017 ; Wang et al, 2017 ; Zingg et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Developmental Patterning and Neurogenetic Gradients of Nurr1 Positive Neurons in the Rat Claustrum and Lateral Cortex

Fang¹,

Wang²,

Naumann³

2021

Front. Neuroanat.

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The claustrum is an enigmatic brain structure thought to be important for conscious sensations. Recent studies have focused on gene expression patterns, connectivity, and function of the claustrum, but relatively little is known about its development. Interestingly, claustrum-enriched genes, including the previously identified marker Nurr1, are not only expressed in the classical claustrum complex, but also embedded within lateral neocortical regions in rodents. Recent studies suggest that Nurr1 positive neurons in the lateral cortex share a highly conserved genetic expression pattern with claustrum neurons. Thus, we focus on the developmental progression and birth dating pattern of the claustrum and Nurr1 positive neurons in the lateral cortex. We comprehensively investigate the expression of Nurr1 at various stages of development in the rat and find that Nurr1 expression first appears as an elongated line along the anterior-posterior axis on embryonic day 13.5 (E13.5) and then gradually differentiates into multiple sub-regions during prenatal development. Previous birth dating studies of the claustrum have led to conflicting results, therefore, we combine 5-ethynyl-2′-deoxyuridine (EdU) labeling with in situ hybridization for Nurr1 to study birth dating patterns. We find that most dorsal endopiriform (DEn) neurons are born on E13.5 to E14.5. Ventral claustrum (vCL) and dorsal claustrum (dCL) are mainly born on E14.5 to E15.5. Nurr1 positive cortical deep layer neurons (dLn) and superficial layer neurons (sLn) are mainly born on E14.5 to E15.5 and E15.5 to E17.5, respectively. Finally, we identify ventral to dorsal and posterior to anterior neurogenetic gradients within vCL and DEn. Thus, our findings suggest that claustrum and Nurr1 positive neurons in the lateral cortex are born sequentially over several days of embryonic development and contribute toward charting the complex developmental pattern of the claustrum in rodents.

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Section: Introductionmentioning

confidence: 99%

Developmental Patterning and Neurogenetic Gradients of Nurr1 Positive Neurons in the Rat Claustrum and Lateral Cortex

Fang¹,

Wang²,

Naumann³

2021

Front. Neuroanat.

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“…Sulf1 was distinctly expressed in the NAcSh, TS, claustrum, dorsal endopiriform nucleus, layer 6 of the cerebral cortex, and PVT. All of these regions are the target areas of the dopaminergic projections from the substantia nigra (SN), VTA, and others ( Björklund and Dunnett, 2007 ; Li et al, 2014 ; Wong et al, 2021 ). In addition, we found that Sulf1- expressing cells were positive for D1R and/or D2R in the above regions ( Figures 8 , 9 , data not shown), suggesting a close relationship between Sulf1 and D1R/D2R.…”

Section: Discussionmentioning

confidence: 99%

Expression of Heparan Sulfate Endosulfatases in the Adult Mouse Brain: Co-expression of Sulf1 and Dopamine D1/D2 Receptors

et al. 2021

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The heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1), and Sulfatase 2 (Sulf2), are extracellular enzymes that regulate cellular signaling by removing 6-O-sulfate from the heparan sulfate chain. Although previous studies have revealed that Sulfs are essential for normal development, their functions in the adult brain remain largely unknown. To gain insight into their neural functions, we used in situ hybridization to systematically examine Sulf1/2 mRNA expression in the adult mouse brain. Sulf1 and Sulf2 mRNAs showed distinct expression patterns, which is in contrast to their overlapping expression in the embryonic brain. In addition, we found that Sulf1 was distinctly expressed in the nucleus accumbens shell, the posterior tail of the striatum, layer 6 of the cerebral cortex, and the paraventricular nucleus of the thalamus, all of which are target areas of dopaminergic projections. Using double-labeling techniques, we showed that Sulf1-expressing cells in the above regions coincided with cells expressing the dopamine D1 and/or D2 receptor. These findings implicate possible roles of Sulf1 in modulation of dopaminergic transmission and dopamine-mediated behaviors.

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“…Another area that might suffer alterations during chronic pain is the claustrum ( Atilgan et al, 2022 ; Ntamati et al, 2023 ), a multimodal node with brain-wide connectivity and involved in several networks ( Atilgan et al, 2022 ). Interestingly, the claustrum also receives dopaminergic inputs from the VTA ( Wong et al, 2021 ), with dopamine causing a mostly inhibitory response of this structure ( Wong et al, 2021 ), although the precise mechanisms of this inhibition are not yet well understood. However, it is interesting to note that an hypodopaminergic state could explain the reduced excitatory drive of the claustrum onto cortical structures like the ACC ( Ntamati et al, 2023 ).…”

Section: Involvement Of the Vta In Pain Processingmentioning

confidence: 99%

Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub

Flores-García,

Rizzo,

Garçon-Poca

et al. 2023

Front. Pharmacol.

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Chronic pain and depression are highly prevalent pathologies and cause a major socioeconomic burden to society. Chronic pain affects the emotional state of the individuals suffering from it, while depression worsens the prognosis of chronic pain patients and may diminish the effectiveness of pain treatments. There is a high comorbidity rate between both pathologies, which might share overlapping mechanisms. This review explores the evidence pinpointing a role for the ventral tegmental area (VTA) as a hub where both pain and emotional processing might converge. In addition, the feasibility of using the VTA as a possible therapeutic target is discussed. The role of the VTA, and the dopaminergic system in general, is highly studied in mood disorders, especially in deficits in reward-processing and motivation. Conversely, the VTA is less regarded where it concerns the study of central mechanisms of pain and its mood-associated consequences. Here, we first outline the brain circuits involving central processing of pain and mood disorders, focusing on the often-understudied role of the dopaminergic system and the VTA. Next, we highlight the state-of-the-art findings supporting the emergence of the VTA as a link where both pathways converge. Thus, we envision a promising part for the VTA as a putative target for innovative therapeutic approaches to treat chronic pain and its effects on mood. Finally, we emphasize the urge to develop and use animal models where both pain and depression-like symptoms are considered in conjunction.

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Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum

Cited by 17 publications

References 200 publications

Developmental Patterning and Neurogenetic Gradients of Nurr1 Positive Neurons in the Rat Claustrum and Lateral Cortex

Developmental Patterning and Neurogenetic Gradients of Nurr1 Positive Neurons in the Rat Claustrum and Lateral Cortex

Expression of Heparan Sulfate Endosulfatases in the Adult Mouse Brain: Co-expression of Sulf1 and Dopamine D1/D2 Receptors

Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub

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