, marked an entry in the history of NASA and the human space missions in general. That day, two female astronauts, Jessica Meir and Christina Koch, made the first in history all-women spacewalk. 1 While human spacewalks have occurred at the International Space Station (ISS) since 1998 and several female astronauts made the joints spacewalks with male astronauts, this symbolic event began the discussion of prospects for space philosophy, as well as space policy. One of the basic challenges human spaceflights face is a hazardous impact of space on humans. This is one of the reasons why a human presence in space is limited to the boundaries of the low Earth orbit. This is not necessarily the only reason for caution. Another cause is the lack of a strong rationale to send humans to space. 2 Linda Billings, writing here in Theology and Science, has argued strongly that we earthlings should not colonize Mars or other planets. 3 However, let us assume we will send space explorers to off-Earth planets and focus our attention only on the medical and physiological issues. The NASA Twins Study gives us a lot of information about the human body and psyche in space, but only about the male body and psyche. 4 There are some differences between male and female resistance to the different factors in space. Some of them provide good reasons to favor females more than males in space. As Mary Robinette Kowal rightly points out, an average female is better adapted to the space environment-precisely, to the microenvironment of the spacecraftdue to the fact that females are statistically smaller, lighter and use fewer consumables. They are also more resistant to stress in space. 5 Mission planners should not ignore such factors, as the space environment is extremely hostile to humans. This challenge is more apparent when the long-term and deep-space human missions are considered, such as missions to Mars and beyond. 6 The main difficulties of long trips in space include space radiation, altered gravity, unfarmable Martian dust, habitat confinement, isolation, distance from Earth and many others-mixed ecological and psychological factors. 7 The question arises-Are humans able to survive such long missions using currently applied countermeasures, such as diet, drugs, exercise or anti-radiation shelters? We yearn to have deep-space astronauts who not only will survive but who will also perform all tasks at the peak capacity. A longterm-about 3 years and longer-mission in space, such as a mission to Mars may be challenging given currently used countermeasures, in this case, pharmaceuticals 8 and the anti-radiation shielding. 9 Human enhancement in general, including gene editing, could be the option for meeting those difficulties. The idea which lies behind gene editing for space is simple and may be explained in three simple steps. First, identify all hazardous factors in space and check if you have effective countermeasures. Second, if you determine that your countermeasures will not work for the long-term missions, consider the possibi...