1988
DOI: 10.1016/0092-8674(88)90029-3
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Changing the RNA polymerase specificity of U snRNA gene promoters

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Cited by 162 publications
(169 citation statements)
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“…PSE swapping experiments between U2 and U6 genes have demonstrated that different PSEs are functionally interchangeable and per se are not responsible for polymerase selection (25,28,35). It is likely, therefore, that the transcription factor(s) bound to the PSE elements directly interacts with both class II and class III transcription factors to assist in RNA polymerase selection.…”
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confidence: 99%
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“…PSE swapping experiments between U2 and U6 genes have demonstrated that different PSEs are functionally interchangeable and per se are not responsible for polymerase selection (25,28,35). It is likely, therefore, that the transcription factor(s) bound to the PSE elements directly interacts with both class II and class III transcription factors to assist in RNA polymerase selection.…”
mentioning
confidence: 99%
“…Like their class II snRNA gene counterparts, class III snRNA genes have similar DSE and PSE configurations but additionally contain a TATA-like sequence at position Ϫ25. The TATA box of class III snRNA genes is required for efficient transcription and functions as the major determinant of RNA Pol III specificity (25,28).The PSE sequence is found almost exclusively in the promoters of snRNA genes and is the only common essential promoter element through which both classes of snRNA genes can be coordinately regulated. PSE swapping experiments between U2 and U6 genes have demonstrated that different PSEs are functionally interchangeable and per se are not responsible for polymerase selection (25,28,35).…”
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“…This approach began to change when it was discovered that some of the genes for small nuclear RNAs (snRNAs) are transcribed by polymerase III whereas most are transcribed by polymerase II (27,32,35,47). All, however, have regulatory sequences which more closely resemble polymerase II than polymerase III promoters: they are entirely upstream of the transcribed gene, have TATA boxes at approximately -30, and use a common upstream activator protein, Oct 1, which also affects polymerase II protein gene promoters (20,22,28,31,51,52). Most surprisingly, simple changes in spacing between the promoter elements could change the RNA polymerase which expressed the snRNA (18,52).…”
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confidence: 99%