Changing the terminology from kidney replacement therapy to kidney support therapy

Raina, Rupesh; Joshi, Hirva; Chakraborty, Ronith

doi:10.1111/1744-9987.13584

Cited by 4 publications

(4 citation statements)

References 127 publications

(190 reference statements)

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“…When present, especially with liver dysfunction, there is a decrease in hepatic clearance of protein by-products and amino acid breakdowns [21], leading to accumulation of ammonia. Hyperammonemia can cause inflammatory cytokine release, cerebral edema, severe disability, and death [22]. Several studies have emphasized a beneficial effect for the use of HVHF in hemodynamically unstable with higher ammonia level patients [23][24][25][26].…”

Section: Hypokalemiamentioning

confidence: 99%

Literature Review of the Efficacy of High-Volume Hemofiltration in Critically Ill Pediatric Patients

et al. 2022

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Background: Pediatric sepsis is a significant public health issue. This condition is exacerbated by rising serum creatinine and inflammatory cytokines that lead to deleterious effects upon the body. The current standard of care involves the use of continuous kidney replacement therapy to remove harmful cytokines until the body returns to homeostasis. In order to promote faster clearance and reduced stay in the ICU, high-volume hemofiltration (HVHF) has shown promise. However, there is a paucity of studies to fully elucidate its benefits. Methods: A literature search was done using PubMed/ MEDLINE and Embase. The literature was reviewed by two independent reviewers, who independently assessed the quality of randomized controlled trials by using the Cochrane risk of bias tool for RCTs and Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized controlled trials. Data were combined from studies with a similar design. Results: The primary endpoint of all-cause mortality was found to be reduced by 40% across all of the pooled studies. For secondary endpoints, significant reductions of serum creatinine were found. Additionally, duration of ICU stays and treatment course was found to be significantly shorter in HVHF patients than the current standard of care. The rate of adverse effects was analyzed, and there was no difference in the proportion of patients developing hypokalemia, hyperkalemia, hypernatremia, or hyponatremia. The proportion of patients developing hyperglycemia was higher in patients undergoing HVHF, whereas the proportions of patients developing bleeding were significantly less in patients undergoing HVHF. One study reported a total number of adverse events between the two groups which were significantly lesser in patients undergoing HVHF. Conclusion: HVHF shows promise as a modality to treat pediatric patients with sepsis. In order to confirm the benefits of this modality, future studies need significantly more patients for analysis.

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Section: Hypokalemiamentioning

confidence: 99%

Literature Review of the Efficacy of High-Volume Hemofiltration in Critically Ill Pediatric Patients

et al. 2022

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“…ESRD as irreversible decline of kidney function requires renal replacement therapy (dialysis or kidney transplantation) or conservative care (symptom management, anaemia control, non‐dialytic correction of fluid and electrolyte imbalance and end‐of‐life care; Alston & Burns, 2015; Raina et al, 2020). The prevalence of ESRD is higher in older patients over 65 years of age (Chen, Knicely, et al,).…”

Section: Introductionmentioning

confidence: 99%

Developing a conceptual model of older patients’ decision‐making process in choosing dialysis or conservative care using meta‐ethnography

Kim

Son

2021

Journal of Advanced Nursing

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Aims:To systematically review and synthesize qualitative evidence related to decisionmaking for treatment modalities among older adults with end-stage renal disease. Design:A meta-synthesis of the qualitative research was conducted. Data sources: A comprehensive literature review using PubMed, CINAHL, PsycINFO, Embase, Web of Sciences and Cochrane was systematically conducted. Qualitative studies published in English from January 2010 to October 2020 were considered. Review methods: Qualitative studies were systematically identified and critically appraised. Data synthesis was performed independently by two reviewers. This review followed the Enhancing Transparency in Reporting the Synthesis of Qualitative Research statement.Results: Seven qualitative studies, with publication years ranging from 2015 to 2019, were included in the analysis. Overall, the review comprised studies with a total of 133 participants aged between 61 and 93 years. Through meta-synthesis, three themes were identified: 'reflecting on treatment options', 'confronting difficult decisions' and 'maintaining hope in everyday life'. Conclusion:Our findings reflect that older adults have varying preferences for treatment options. These preferences are influenced by various factors such as considering

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Section: Introductionmentioning

confidence: 99%

“…In severe cases, the treatment should be combined with kidney replacement therapy (KRT) [ 11 , 20 ], but there is no consensus in the modality and timing of KRT [ 21 , 22 ]. Early introduction of KRT has been proven to be kidney protective with better long-term kidney survival [ 20 , 22 ]. In comparative studies of early and late initiation of dialysis, the increase in the frequency of cannula sepsis was highlighted as a major disadvantage [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Daily serum phosphate increase as early and reliable indicator of kidney injury in children with leukemia and lymphoma developing tumor lysis syndrome

et al. 2023

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Background Tumor lysis syndrome (TLS) and its most serious complication, acute kidney injury (AKI) are one of the emergency conditions in onco-hematology. It is difficult to predict the degree of kidney involvement. Therefore, we studied children with leukemia and lymphoma treated in four Hungarian tertiary centers (inpatient university clinics) retrospectively (2006–2016) from a nephrological aspect. Method Data of 31 pediatric patients were obtained from electronic- and paper-based medical records. Physical status, laboratory test results, treatments, and outcomes were assessed. Patients were analyzed according to both “traditional” TLS groupings, as laboratory TLS or clinical TLS, and nephrological aspect based on pRIFLE classification, as mild or severe AKI. Results Significant differences were found between the changes in parameters of phosphate homeostasis and urea levels in both classifications. Compared to age-specific normal phosphate ranges, before the development of TLS, hypophosphatemia was common (19/31 cases), while in the post-TLS period, hyperphosphatemia was observed (26/31 cases) most frequently. The rate of daily change in serum phosphate level was significant in the nephrological subgroups, but peaks of serum phosphate level show only a moderate increase. The calculated cut-off value of daily serum phosphate level increased before AKI was 0.32 mmol/L per ROC analysis for severe TLS–AKI. The 24-h urinalysis data of eight patients revealed transiently increased phosphate excretion only in those patients with TLS in whom serum phosphate was elevated in parallel. Conclusion Daily serum phosphate level increase can serve as a prognostic factor for the severity of pediatric TLS, as well as predict the severity of kidney involvement. Graphical abstract

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Changing the terminology from kidney replacement therapy to kidney support therapy

Cited by 4 publications

References 127 publications

Literature Review of the Efficacy of High-Volume Hemofiltration in Critically Ill Pediatric Patients

Literature Review of the Efficacy of High-Volume Hemofiltration in Critically Ill Pediatric Patients

Developing a conceptual model of older patients’ decision‐making process in choosing dialysis or conservative care using meta‐ethnography

Daily serum phosphate increase as early and reliable indicator of kidney injury in children with leukemia and lymphoma developing tumor lysis syndrome

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