Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study

Abstract

Background: It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of nonalcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of new-onset NAFLD. Methods:We explored the relationship between SUA trajectories and NAFLD in a cohort including 3822 participants. Individual's SUA trajectories from 2012 to 2014 were defined using group-based trajectory modeling analysis in four distinct patterns: trajectory 1 (n = 991, 25.93%), trajectory 2 (n = 1421, 37.18%), trajectory 3 (n = 1156, 30.22%), and trajectory 4 (n = 254, 6.67%). The logistic regression model was used to evaluate the association between SUA changing trajectories and subsequent NAFLD until 2016. Dose-response relationship between SUA changing trajectories and NAFLD risk was evaluated through the testing of trajectory groups as a continuous variable. Results:The 2-year incidence of NAFLD was 13.27%. Compared with trajectory 1, the adjusted odds risk for NAFLD development was in a dose-response relationship as follows: 1.27 (95% CI 0.91-1.78) for trajectory 2, 1.89 (95% CI 1.29-2.75) for trajectory 3, and 2.34 (95% CI 1.43-3.83) for trajectory 4. And this dose-response relationship was not affected by age, sex, and abdominal obesity. Conclusions:Higher SUA changing trajectory is a risk factor for NAFLD. This finding highlights the importance of paying attention to SUA changing trajectory on the detection and prevention of NAFLD.

Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

“…Furthermore, we could not incorporate the fatty liver into the structural equation modeling diagram of respiratory function and UA levels in females (Figure 5E) because the parameters did not converge. As was the case with the previous studies [51][52][53], although the prevalence of fatty liver disease was greater in subjects with high UA levels than in those with low UA levels among male and female subjects (Supplementary Tables S1 and S2), age, but not fatty liver disease, was significantly associated with a decrease in the FEV1/FVC value (Supplementary Table S3). In our clinical investigation, we focused on an aging-dependent decline in lung function as the respiratory dysfunction in humans.…”

Prevalence and risk factors of metabolic-associated fatty liver disease during 2014–2018 from three cities of Liaoning Province: an epidemiological survey

“…Regarding the correlation between SUA and MAFLD, SUA elevation was reported as one of the risk factors for MAFLD. 26 Although genetic susceptibility was not examined in the current study, it is involved in NAFLD. Polymorphisms in PNPLA3, 27 SREBF-2, 28 CETP 28 29 and APOC3 30 Open access been found to be associated with lean NAFLD.…”

“…Regarding the correlation between SUA and MAFLD, SUA elevation was reported as one of the risk factors for MAFLD. 26 …”

A simpler definition of MAFLD better predicts long-term all-cause mortality in American adults

“…Besides, because hs-CRP, an indicator of relatively low specificity, is not routinely measured in clinical practice across regions, we propose that it be excluded from the diagnostic criteria, echoing an expert consensus from the Middle East and North Africa [7]. Moreover, as emerging evidence has suggested the critical role of hyperuricemia in the development of fatty liver [8][9][10], we included hyperuricemia in the simplified criteria.…”