Objective:The aim of this study is to evaluate three denture adhesives in retention and masticatory efficiency in edentulous patients wearing complete maxillary and mandibular dentures. Subjects and Methods: Thirteen completely edentulous patients were selected from the Outpatient Clinic of the Prosthodontic Department; Faculty of Dental medicine, Al Azhar University. Three complete denture adhesive types (Fitty dent cushion, Protefix cream and Mucopren liner) were used. A digital force meter was used to objectively measure retention strength afforded in grams. Chewing efficiency measured by chewing gum. Results: measurement showed significant difference in dentures retention. Improvement of the chewing ability was observed by the using of different adhesive types and there was significant difference between the different adhesives. The direct measurement of dentures retention showed that a significant improvement in dentures retention was observed when the cream type, liner type, or cushion type denture adhesive was used. And that Protefix cream offers the best retention performance, followed by Fitty dent cushion, and finally Mucopren liner offers the lowest retention performance. Conclusion: The clinical value of a denture adhesive relates to improvement of function and its effect on the underlying tissue health. There is sufficient information to support the use of denture adhesives to increase denture retention, stability, and incisive ability for ill, fair, and well-fitting prostheses. Also, the use of adhesive creams significantly increased the denture retention.