Changing Trends in Melanoma Incidence and Decreasing Melanoma Mortality in Hungary Between 2011 and 2019: A Nationwide Epidemiological Study

Liszkay, Gabriella; Kiss, Zoltán; Gyulai, Rolland; Oláh, Judit; Holló, Péter; Emri, Gabriella; Csejtei, András; Kenessey, István; Benedek, Angéla; Polányi, Zoltán; Nagy-Erdei, Zsófia; Daniel, Andrea R.; Knollmajer, Kata; Várnai, Máté; Vokó, Zoltán; Nagy, Balázs; Rokszin, György; Fábián, Ibolya; Barcza, Zsófia; Polgár, Csaba

doi:10.3389/fonc.2020.612459

Cited by 16 publications

(28 citation statements)

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“…The mortality of melanoma showed increasing trends, similarly to incidence (6,7), however, there are regions where mortality is decreasing (8)(9)(10), including Europe (ASR per 100,000 in 2012: 3.1 for males, 1.9 for females, in 2018: 2.8 for males, 1.7 for females) (4,5). Our recent epidemiological study presented a change in Hungarian melanoma incidence trend in the last decade and confirmed a decrease in mortality, as well (11).…”

Section: Introductionsupporting

confidence: 73%

“…Different standardization was necessary to allow for a direct comparison with recent GLOBOCAN data that uses the ESP 1976 dataset for European analyses and to evaluate the change of melanoma MIR in recent years (ESP 2013). More details on the identification of patients with malignant melanoma were described in our previous article where we reported the main epidemiology results of our study (11).…”

Section: Methodsmentioning

confidence: 99%

“…Using population level data allows us to measure the size and change of MIR and position Hungary accurately among European countries in aspect of MIR. Previously we found that age-standardized incidence rates were higher in males and varied between 28.28 and 34.57/100,000 person-years (PYs), and between 22.63 and 26.72/100,000 PYs in females and mortality rates varied between 4.73 and 5.98/100,000 PYs in males and between 2.33 and 3.20/100,000 PYs in females (11).…”

Section: Introductionmentioning

confidence: 95%

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Improving Quality Indicator of Melanoma Management – Change of Melanoma Mortality-to-Incidence Rate Ratio Based on a Hungarian Nationwide Retrospective Study

et al. 2021

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IntroductionThe incidence of melanoma has been increasing in the last decades. A retrospective Hungarian epidemiological study provided real-world data on incidence and mortality rates. There have been changing trends in incidence in Hungary in the last decade and mortality decreased, shifting mortality-to-incidence rate ratios (MIR). MIR is an indicator of cancer management quality.ObjectivesOur aim is to show the changes of melanoma MIR in Hungary between 2011 and 2018 and to compare the real-world evidence-based results of our Hungarian nationwide retrospective study with other European countries.MethodsMIR is calculated from the age-specific standardized incidence and mortality rates from our study. Annual MIR values are presented for the total population and for both sexes between 2011 and 2018, along with 95% confidence intervals. Comparison with European countries are shown for 2012 and 2018 based on the GLOBOCAN database and Eurostat health care expenditure per capita data.ResultsMIR decreased by 0.035 during the study years. The decrease was same in both sexes (0.031). Male had higher MIRs in all study years. In both 2012 and 2018, Hungarian MIR in both sexes was lower than the European Union average (males: 0.192 vs. 0.212 and 0.148 vs. 0.174 respectively, women: 0.107 vs. 0.129 and 0.083 vs. 0.107 respectively).DiscussionHungarian mortality-to-incidence ratio is the lowest in Central and Eastern Europe and is close to the level of Western and Northern European countries. The results are driven by the high number of new diagnosed melanoma cases.

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Section: Introductionsupporting

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Improving Quality Indicator of Melanoma Management – Change of Melanoma Mortality-to-Incidence Rate Ratio Based on a Hungarian Nationwide Retrospective Study

et al. 2021

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“…Recently, incidence rates of melanoma were documented as high as 35 cases in 100,000 in Australia and around 14 cases in 100,000 in both the USA and UK [1]. In 2019, 24 new melanoma cases per 100,000 inhabitants were diagnosed in Hungary according to the National Health Insurance Fund of Hungary (NHIF) [3]. A recent study found 2 of 13 significant changes in melanoma incidence trends in Hungary.…”

Section: Introductionmentioning

confidence: 99%

“…Between 2011 and 2015, a significant mean annual increase was detected in the overall melanoma incidence, while between 2015 and 2019, a relevant mean annual decrease was seen. The authors assumed that joining the Euromelanoma campaign supported existing Hungarian seasonal screening programs to reach a wider population leading to the decline [3].…”

Section: Introductionmentioning

confidence: 99%

Results of a Primary Skin-Cancer-Prevention Campaign in Early Childhood on Sun-Related Knowledge and Attitudes in Southern Hungary

Horváth

Evelin

Oláh

et al. 2021

Cancers

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Avoidance of ultraviolet (UV) exposure in early childhood is important for reducing the lifetime risk of developing skin cancer. The goal of the present prospective, multicenter pilot study was to assess the sun-protection practices in kindergartens and daycare centers and to evaluate sun protection knowledge and behavior among caregivers employed in the surveyed facilities. The study consisted of two parts. A baseline questionnaire was completed by the caregivers in relation to knowledge regarding basic sun protection and sun protection practices of the participating facilities. Afterward, a thirty-minute presentation was hosted in reference to this topic. Six months following the presentation, a follow-up questionnaire was distributed among the caregivers, evaluating the attitude-related and behavioral changes towards children. A total of 153 caregivers from five daycare centers (children between 6 months and 3 years of age) and sixteen kindergartens (children between 3 and 7 years of age) willfully participated in our study. According to our results, the main source of information regarding sun protection originated from different types of media. We found that staying in shaded areas and the use of protective clothing were not frequent in the facilities. Following our presentation regarding skin types and sunscreen use, protective measures improved, but not significantly (p = 0.222). The majority (92.31%) of caregivers distributed the information throughout their environment and also to parents. Sun protection knowledge is necessary; however, motivation among caregivers and parents and involvement of children is also relevant. Hence, a continuous, repetitive educational program regarding sun-smart behavior is deemed essential.

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Differences in Thickness-Specific Incidence and Factors Associated With Cutaneous Melanoma in the US From 2010 to 2018

et al. 2022

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ImportanceThe recent incidence of cutaneous melanoma of different thicknesses in the US is not well described.ObjectiveTo evaluate recent patterns in the incidence of melanoma by tumor thickness and examine associations of sex, race and ethnicity, and socioeconomic status with melanoma thickness-specific incidence.Design, Setting, and ParticipantsThis population-based cohort study analyzed data for 187 487 patients with a new diagnosis of invasive cutaneous melanoma from the Surveillance, Epidemiology, and End Results Registry from January 1, 2010, to December 31, 2018. The study was conducted from May 27 to December 29, 2021. Data were analyzed from June 21 to October 24, 2021.Main Outcomes and MeasuresAge-adjusted incidence rates of melanoma were calculated by tumor thickness (categorized by Breslow thickness) and annual percentage change (APC) in incidence rates. Analyses were stratified by sex and race and ethnicity. The associations with socioeconomic status were evaluated in 134 359 patients diagnosed with melanoma from 2010 to 2016.ResultsThis study included 187 487 patients with a median (IQR) age of 62 (52-72) years and 58.4% men. Melanoma incidence was higher in men compared with women across all tumor thickness groups. Individuals in lower socioeconomic status quintiles and members of minority groups were more likely to be diagnosed with thicker (T4) tumors (20.7% [169 of 816] among non-Hispanic Black patients, 11.2% [674 of 6042] among Hispanic patients, and 6.3% [10 774 of 170 155] among non-Hispanic White patients). Between 2010 and 2018, there was no significant increase in incidence of cutaneous melanoma across the full population (APC, 0.39%; 95% CI, –0.40% to 1.18%). The incidence of the thickest melanomas (T4, >4.0 mm) increased between 2010 and 2018, with an APC of 3.32% (95% CI, 2.06%-4.60%) overall, 2.50% (95% CI, 1.27%-3.73%) in men, and 4.64% (95% CI, 2.56%-6.75%) in women.Conclusions and RelevanceIn this population-based cohort study, the incidence of the thickest cutaneous melanoma tumors increased from 2010 to 2018, in contrast with the incidence patterns for thinner melanomas. The findings suggest potential stabilization of overall melanoma incidence rates in the US after nearly a century of continuous increase in incidence. Patients with low socioeconomic status and Hispanic patients were more likely to be diagnosed with thick melanoma. The continued rise in incidence of thick melanoma is unlikely to be attributable to overdiagnosis given the stability of thin melanoma rates.

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Changing Trends in Melanoma Incidence and Decreasing Melanoma Mortality in Hungary Between 2011 and 2019: A Nationwide Epidemiological Study

Cited by 16 publications

References 45 publications

Improving Quality Indicator of Melanoma Management – Change of Melanoma Mortality-to-Incidence Rate Ratio Based on a Hungarian Nationwide Retrospective Study

Improving Quality Indicator of Melanoma Management – Change of Melanoma Mortality-to-Incidence Rate Ratio Based on a Hungarian Nationwide Retrospective Study

Results of a Primary Skin-Cancer-Prevention Campaign in Early Childhood on Sun-Related Knowledge and Attitudes in Southern Hungary

Differences in Thickness-Specific Incidence and Factors Associated With Cutaneous Melanoma in the US From 2010 to 2018

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