Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Tang, Hongwei; Zhang, Nan; Deng, Jianchuan; Zhou, Kang

doi:10.1111/eci.14098

Cited by 3 publications

References 38 publications

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Investigating the prevalence burden of peptic ulcer disease in older adults aged 70+ from 1990 to 2019: an analysis of Global Disease Burden Studies

Zhuo,

Fang,

Yin

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Background Peptic ulcer disease (PUD) affects individuals aged ≥70 years globally, exerting a significant impact on their health and well-being. Understanding its epidemiological evolution and associated factors is crucial for guiding interventions and improving management. Methods This study utilized Global Burden of Disease Study data to examine the prevalence and temporal changes of PUD in individuals aged 70 years and older between 1990 and 2019. The analysis included assessing estimated annual percentage changes (EAPCs) to investigate temporal trends and regional variations. Results Over the past 30 years, the number of individuals aged 70 years and above suffering from PUD globally has increased from 1 065 730 cases in 1990 to 1 608 463 cases in 2019. Despite an increasing number of cases, the prevalence of PUD among the elderly has exhibited a steady decline, with an EAPC of −1.47 (95% confidence interval: −1.57 to −1.37) over this timeframe. In 2019, the prevalence rates of PUD among individuals aged 70–74, 75–79, 80–84, and 85 years and older were 313.36, 365.77, 388.45, and 352.51 per 100 000 population, respectively. South Asia, high-income North America, and Central Sub-Saharan Africa were the regions with the highest prevalence rates of PUD in 2019, with rates of 624.90, 575.48, and 474.80 per 100 000 population, respectively. At the national level, Ireland, Australia, Brazil, Brunei Darussalam, and Bangladesh have effectively managed the burden of PUD among the elderly, achieving the greatest reduction. Additionally, regions with higher levels of socioeconomic development tended to have relatively lower burdens of PUD among the elderly, and prevalence rates varied across different regions and age groups. Conclusion Our study highlights the enduring burden of PUD among the global elderly population, emphasizing the significance of tailored interventions to address this pressing issue. This research underscores the critical need for targeted public health strategies aimed at improving outcomes specifically for older adults affected by PUD.

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Investigating the prevalence burden of peptic ulcer disease in older adults aged 70+ from 1990 to 2019: an analysis of Global Disease Burden Studies

Zhuo,

Fang,

Yin

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019

Zhang,

Liu,

et al. 2024

JAHA

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Background The aim of this study was to characterize the burden of valvular heart disease (VHD)‐related heart failure (HF) in Group of 20 (G20) countries. Methods and Results Using data from the 2019 Global Burden of Disease Study, we estimated VHD‐related HF burdens (cases, age‐standardized prevalence rates, and years lived with disabilities rates) in G20 countries from 1990 to 2019 by age, sex, and sociodemographic index. The burden of VHD‐related HF increased in G20 countries from 1990 to 2019, exhibiting heterogeneity across VHD subtypes. In 2019, Italy, the United States, and the Russian Federation had the highest age‐standardized prevalence rates of nonrheumatic VHD‐related HF, whereas India, Brazil, and Mexico had the lowest. Rheumatic VHD‐related HF was most prevalent in China, India, and Italy, whereas the Republic of Korea, Brazil, and Turkey had the lowest. Nonrheumatic VHD‐related HF prevalence peaked among G20 countries in individuals ≥85 years of age, whereas rheumatic VHD‐related HF peaked in those 75 to 84 years of age in several countries, including China, India, the Russian Federation, Mexico, Argentina, and Turkey. Age‐standardized prevalence rates of nonrheumatic VHD‐related HF showed a decreasing trend, more pronounced in women, whereas rheumatic VHD‐related HF increased in both sexes, with a lower increase in men. Nonrheumatic VHD‐related HF burden correlated with age and sociodemographic index, whereas rheumatic VHD‐related HF burden was highest in middle sociodemographic index countries for those <75 years of age. Years lived with disabilities rates for VHD‐related HF represented about 9.0% of the overall burden across populations. Conclusions The increasing burden of VHD‐related HF in G20 countries highlights the need for timely interventions to mitigate this growing public health challenge.

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Heart Failure Attributable to Hemoglobinopathies and Hemolytic Anemia: A Three-Decade Cross-Sectional Assessment of the Global Burden

Deng,

Yu,

et al. 2024

Preprint

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Background Complexity of anemia subtypes remains unresolved, and therapies targeting anemia have inconsistently improved heart failure (HF) outcomes. This study aims to assess the prevalence trend and contributing factors of HF impairment with hemoglobinopathies and hemolytic anemia at global, regional and national levels. Main body of the abstract: Utilizing Global Burden of Disease (GBD) data for HF and hemoglobinopathies inclusive of hemolytic anemia, we systematically gathered annual figures for prevalence and incidence. Estimated Annual Percentage Changes (EAPCs) were computed to assess temporal trends in these diseases. Estimates were subsequently disaggregated by sex, geographical regions, and national levels to present a concise yet detailed picture of the disease dynamics globally. During the past three decades, although the absolute caseloads of hemoglobinopathies and hemolytic anemias grew without altering their standardized prevalence (EAPC = 0.26), the rate of heart failure compounded by anemia sharply rose (EAPC = 0.49). Notably, in high Sociodemographic Index (SDI) regions, the HF-to-hematological disorder ratio ascended more rapidly, moving from 82.80 parts per million (ppm) in 1990 to 114.22 ppm in 2019, surpassing the worldwide average increment (40 ppm). Despite greater anemia-related burdens among females, male patients experienced a disproportionately higher frequency of heart failure. Short conclusion: Over the past three decades, there has been a steady rise in the prevalence of heart failure comorbid with hemoglobinopathies and hemolytic anemias, with a more pronounced disease burden observed among men and a discernible shift toward High SDI regions.

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Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Cited by 3 publications

References 38 publications

Investigating the prevalence burden of peptic ulcer disease in older adults aged 70+ from 1990 to 2019: an analysis of Global Disease Burden Studies

Investigating the prevalence burden of peptic ulcer disease in older adults aged 70+ from 1990 to 2019: an analysis of Global Disease Burden Studies

Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019

Heart Failure Attributable to Hemoglobinopathies and Hemolytic Anemia: A Three-Decade Cross-Sectional Assessment of the Global Burden

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