Changing Trends of Breast Cancer Survival in Sultanate of Oman

Kumar, Shiyam; Burney, Ikram A.; Al-Ajmi, A.; Al-Moundhri, Mansour

doi:10.1155/2011/316243

Cited by 46 publications

(56 citation statements)

References 17 publications

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“…Lung cancer was fourth, most likely because smoking was uncommon in Oman until after 1970; breast cancer, thyroid cancer and cervical cancers were the most common cancer in women (Nooyi and Al-Lawati, 2011). The majority of patients with cancer in Oman tend to present at advanced stages, at younger age and with low survival rates even though up to date treatment modalities are available (Kumar et al, 2011). Furthermore, there are no early screening programs for the majority of cancers, except for breast cancer which was introduced in 2010 (Ministry of Health, 2010a).…”

Section: Awareness Of Risk Factors For Cancer Among Omani Adults-a Comentioning

confidence: 99%

Awareness of Risk Factors for Cancer among Omani adults- A Community Based Study

Al-Azri

Al-Rasbi

Al-Hinai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Cancer is the leading cause of mortality around the world. However, the majority of cancers occur as a result of modifiable risk factors; hence public awareness of cancer risk factors is crucial to reduce the incidence. The objective of this study was to identify the level of public awareness of cancer risk factors among the adult Omani population. Conclusions:The majority of respondents in this study in Oman were not aware of the common risk factors for cancer. It may be possible to reduce the incidence of cancers in Oman by developing strategies to educate the public about these risk factors.

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Section: Awareness Of Risk Factors For Cancer Among Omani Adults-a Comentioning

confidence: 99%

Awareness of Risk Factors for Cancer among Omani adults- A Community Based Study

Al-Azri

Al-Rasbi

Al-Hinai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The advanced stage of presentation of breast cancer in developing countries is due to lack of mass education and screening programs, poverty, poor access to health care facilities, lack of expertise, and poor country resources. 4 There is worldwide variation as well for cancer survival. 5-year relative survival for breast, colorectal, and prostate cancer was higher in North America, Australia, Japan, and northern, western, and southern Europe and lower in Algeria, Brazil, and Eastern Europe.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Zaid

Nuzhat

Rafiqe

2017

Int J Community Med Public Health

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INTRODUCTIONBreast cancer (BC) is a major health problem in both developed and developing countries. Around the World, nearly 1.7 million new breast cancer cases were diagnosed in 2012 and this figure represented about 12% of all new cancer cases and 25% of all cancers in women. Since 2008, worldwide breast cancer incidence has increased by more than 20% and mortality has increased by 14 %. ABSTRACTBackground: Breast cancer is the most frequently diagnosed cancer among women in 140 of 184 countries worldwide. The association between breast cancer survival and socio-demographic and pathologic factors has been widely studied in the developed countries. But scarce data is available from Saudi Arabia. We aimed to determine the overall observed one year and three years survival rate of female breast cancer patients and to investigate the factors affecting survival rate. Methods: Retrospective data was collected from the cancer center registry at King Fahad Medical City (KFMC) that included all women diagnosed with breast cancer between 1 st January 2011 till 31 st December 2012 and were followed to 31 st December 2015 (cut off point for follow-up). Kaplan-Meier analysis was done to assess overall survival. The factors affecting survival rate such as age, histological type, tumor grade at diagnosis, metastases and treatment options were investigated using log rank test and Cox regression analysis. Results: The overall observed survival probability of the study population at 1, and 3 years was 95%, and 85%, respectively. The 3 year survivals for the younger (≤40 years), 41-50 years and older (50+ years) patients were 83.9%, 90.6% and 80.6% respectively, the differences not reaching statistical significance. There were statistically significant associations between three year survival and histological type of tumour, laterality, metastases and type of treatment by the univariate analysis log rank test. Conclusions: One and three-year survival rate of breast cancer at KFMC was 96% and 85% respectively. Investigating the factors affecting survival rate is one of the most essential means of improving cancer prognosis.

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“…Breast cancer is the most common malignancy in women throughout the world, and it accounts for 18% of all female cancers and there are approximately 600,000 annual deaths worldwide (Kumar et al, 2011). Chemotherapy is the principal therapeutic option to treat cancer patients but emerging drug resistance, tumor relapse and post treatment toxicity limits their use in clinic and these hurdles facilitates breast cancer as number one killer in women (Carol et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation

Bakshi¹,

Hakkim²,

Sam³

2016

Asian Pacific Journal of Cancer Prevention

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Background: Crocus sativus and its major constituent crocin are well established to have anti-cancer properties in breast cancer cells (MCF-7). However the role of C. sativus extract (CSE) and crocin on caspase signaling mediated MCF-7 cell death at molecular level is remains unclear. In this study, we tried to unravel role of CSE and crocin on caspase mediated MCF-7 cells death and their in vivo preclinical toxicity profiling and immune stimulatory effect. Materials and Methods: CSE extract was fractionated by HPLC and crocin was isolated and characterized by NMR, IR, and MS. MCF-7 cells were treated with both CSE and crocin and expression of Bcl-2 and Bax was assessed after 24 and 36 hours. Furthermore, caspase 3, caspase 8 and caspase 9 expression was determined by Western blotting after 24 hours of treatment. DNA fragmentation analysis was performed for genotoxicity of CSE and crocin in MCF-7 cells. The in vivo toxicity profile of CSE (300 mg/kg of b.wt) was investigated in normal Swiss albino mice. In addition, peritoneal macrophages were collected from crocin (1, 1.5 and 2 mg/kg body weight) treated mice and analyzed for ex vivo yeast phagocytosis. Results: Immunoblot analysis revealed that there was time dependent decline in anti-apoptotic Bcl-2 with simultaneous upregulation of Bax in CSE and crocin treated MCF-7 cells. Further CSE and crocin treatment downregulated caspase 8 and 9 and cleaved the caspase 3 after 24 hours. Both CSE and crocin elicited considerable DNA damage in MCF-7 cells at each concentration tested. In vivo toxicity profile by histological studies revealed no observable histopathologic differences in the liver, kidney, spleen, lungs and heart in CSE treated and untreated groups. Crocin treatment elicited significant dose and time dependent ex vivo yeast phagocytosis by peritoneal macrophages. Conclusions: Our study delineated involvement of pro-apoptotic and caspase mediated MCF-7 cell death by CSE and crocin at the molecular level accompanied with extensive DNA damage. Further we found that normal swiss albino mice can tolerate the maximum dose of CSE. Crocin enhanced ex vivo macrophage yeast phagocytic ability.

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Changing Trends of Breast Cancer Survival in Sultanate of Oman

Cited by 46 publications

References 17 publications

Awareness of Risk Factors for Cancer among Omani adults- A Community Based Study

Awareness of Risk Factors for Cancer among Omani adults- A Community Based Study

Factors affecting survival of women with breast cancer in King Fahad Medical City, Saudi Arabia

Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation

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