The physics program in Hall A at Jefferson Lab commenced in the summer of 1997 with a detailed investigation of the 16 O(e, e ′ p) reaction in quasielastic, constant (q, ω) kinematics at Q 2 ≈ 0.8 (GeV/c) 2 , q ≈ 1 GeV/c, and ω ≈ 445 MeV. Use of a self-calibrating, self-normalizing, thin-film waterfall target enabled a systematically rigorous measurement. Five-fold differential cross-section data for the removal of protons from the 1p-shell have been obtained for 0 < pmiss < 350 MeV/c. Six-fold differential cross-section data for 0 < Emiss < 120 MeV were obtained for 0 < pmiss < 340 MeV/c. These results have been used to extract the ALT asymmetry and the RL, RT , RLT , and RL+T T effective response functions over a large range of Emiss and pmiss. Detailed comparisons of the 1p-shell data with Relativistic Distorted-Wave Impulse Approximation (rdwia), Relativistic Optical-Model Eikonal Approximation (romea), and Relativistic Multiple-Scattering Glauber Approximation (rmsga) calculations indicate that two-body currents stemming from Meson-Exchange Currents (MEC) and Isobar Currents (IC) are not needed to explain the data at this Q 2 . Further, dynamical relativistic effects are strongly indicated by the observed structure in ALT at pmiss ≈ 300 MeV/c. For 25 < Emiss < 50 MeV and pmiss ≈ 50 MeV/c, proton knockout from the 1s 1/2 -state dominates, and romea calculations do an excellent job of explaining the data. However, as pmiss increases, the single-particle behavior of the reaction is increasingly hidden by more complicated processes, and for 280 < pmiss < 340 MeV/c, romea calculations together with two-body currents stemming from MEC and IC account for the shape and transverse nature of the data, but only about half the magnitude of the measured cross section. For 50 < Emiss < 120 MeV and 145 < pmiss < 340 MeV/c, (e, e ′ pN ) calculations which include the contributions of central and tensor correlations (two-nucleon correlations) together with MEC and IC (two-nucleon currents) account for only about half of the measured cross section. The kinematic consistency of the 1p-shell normalization factors extracted from these data with respect to all available 16 O(e, e ′ p) data is also examined in detail. Finally, the Q 2 -dependence of the normalization factors is discussed.