The traditional methods for multi-focus image fusion, such as the typical multi-scale geometric analysis theory-based methods, are usually restricted by sparse representation ability and the transferring efficiency of the fusion rules for the captured features. Aiming to integrate the partially focused images into the fully focused image with high quality, the complex shearlet features-motivated generative adversarial network is constructed for multi-focus image fusion in this paper. Different from the popularly used wavelet, contourlet, and shearlet, the complex shearlet provides more flexible multiple scales, anisotropy, and directional sub-bands with the approximate shift invariance. Therefore, the features in complex shearlet domain are more effective. With of help of the generative adversarial network, the whole procedure of multi-focus fusion is modeled to be the process of adversarial learning. Finally, several experiments are implemented and the results prove that the proposed method outperforms the popularly used fusion algorithms in terms of four typical objective metrics and the comparison of visual appearance.