In this article, we propose unit vectors in the high dimensional Cartesian coordinate system as the preamble, and then propose a semiblind timing synchronization and channel estimation scheme for orthogonal frequency division multiplexing (OFDM) systems. Due to the lack of useful information in the time-domain, a frequency-domain timing synchronization algorithm is proposed. The proposed semiblind approach consists of three stages. In the first stage, a coarse timing offset related to the delayed timing of the path with the maximum gain in multipath fading channels is obtained. Then, a fine time adjustment algorithm is performed to find the actual delayed timing in channels. Finally, the channel response in the frequency-domain is obtained based on the final timing estimate. Although the required number of additions in the proposed algorithm is higher than those in conventional methods, the simulation results show that the proposed approach has excellent performance of timing synchronization in several channel models at signal-to-noise ratio (SNR) smaller than 6 dB. In addition, for a low-density parity-check coded single-input single-output OFDM system, our proposed approach has better bit-error-rate performance than conventional approaches for SNR varying from 3 to 8 dB.