Channeling of exogenous phenylalanine to the sites of storage and the sites of alkaloid and protein biosynthesis in Penicillium cyclopium

Nover, Lutz; Lerbs, W.; Müller, Wieland; Luckner, Martin

doi:10.1016/0304-4165(79)90272-1

Cited by 14 publications

(6 citation statements)

References 18 publications

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“…It is interesting that compartmentation of phenylalanine exists in this organism so that exogenous phenylalanine mainly goes to protein whereas endogenous phenylalanine is incorporated predominantly into alkaloids (47).…”

Section: Enzyme Inductionmentioning

confidence: 99%

Regulation of secondary metabolism in fungi

Demain¹

1986

Pure and Applied Chemistry

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Section: Enzyme Inductionmentioning

confidence: 99%

Regulation of secondary metabolism in fungi

Demain¹

1986

Pure and Applied Chemistry

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“…Such separation between a storage and a metabolically active pool often occurs in different eucaryotic cells. It was originally observed for amino acids in yeast cells (7,31) and was described for Neurospora crassa (2,6,22), alkaloid-producing Penicillium cyclopium (16), plants (17), and, in a modified form, animal cells (5,9). However, the isolation of the storage pool is restricted so far to few examples (14,22,31).…”

Section: Discussionmentioning

confidence: 99%

Compartmentation of uracil in Euglena gracilis.

Wasternack¹

1983

Mol. Cell. Biol.

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Compartmentation of uracil in the flagellate Euglena gracilis was studied by tracer-kinetic experiments. Lag times in the equilibration of exogenously given and intracellularly present uracil before linear labeling of catabolic and anabolic products was determined to estimate the size of its metabolically active pool. This pool operates in the incorporation and degradation of uracil. There were the same lag times in forming both final products when measured in parallel and when measured after preloading with pyrimidines, in different cell strains, and under various environmental conditions. The amount of the metabolically active uracil pool, estimated as 11 pmol/10(7) heterotrophically growing cells, decreased to almost zero during light-induced RNA synthesis and could be changed by preloading with uracil or thymine. Besides this metabolic pool, cells may contain large amounts of uracil in a membrane-enclosed storage compartment (up to 12 nmol/10(7) cells). This is metabolically inert, but may be mobilized by nitrogen-carbon starvation. The role of uracil compartmentation in this metabolically flexible organism is discussed.

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“…2) (2.7 pmol/cm2 culture area . sec, 48 hours after inoculation), but zero with respect to the alkaloids. In the phase of maximum alkaloid formation (i.e.…”

Section: Anthranilate Adenylyltransferase Activitymentioning

confidence: 95%

Alkaloid Biosynthesis in Penicillium cyclopium--Does It Reflect General Features of Secondary Metabolism?

Luckner¹

1980

J. Nat. Prod.

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Channeling of exogenous phenylalanine to the sites of storage and the sites of alkaloid and protein biosynthesis in Penicillium cyclopium

Cited by 14 publications

References 18 publications

Regulation of secondary metabolism in fungi

Regulation of secondary metabolism in fungi

Compartmentation of uracil in Euglena gracilis.

Alkaloid Biosynthesis in Penicillium cyclopium--Does It Reflect General Features of Secondary Metabolism?

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