The aim of this research is to identify the socio-economic determinants of divorce in Turkey and four sub regions in the 2008-2017 period by the panel data analysis. Also, this research examine whether the female employment on divorce differs by sector or not. According to analysis findings, per capita income level, female employment in agriculture sector, female education level and male unemployment level have a positive effect on divorce across the Turkey. These impacts differ between regions classified by socioeconomic development. Income level and education level of women are the main determinants of divorce in the regions with high socioeconomic development level, whereas female education level and male unemployment level are the main determinants of divorce in low socioeconomic development level regions. In addition, the effect of female employment on divorce rate varies between agriculture and nonagricultural sectors. The reason for this difference is that the independence effect is more dominant than the income effect on working woman in the agricultural sector and the independence and income effects are not dominant over each other on working woman in the industry and service sectors.