2019
DOI: 10.1101/807909
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Channelrhodopsin C1C2: Photocycle kinetics and interactions near the central gate

Abstract: Channelrhodopsins (ChR) are cation channels that can be expressed heterologously in various living tissues, including cardiac and neuronal cells. To tune spatial and temporal control of potentials across ChR-enriched cell membranes, it is essential to understand how pore hydration impacts the ChR photocycle kinetics. Here, we measure channel opening and closing rates of channelrhodopsin chimera and selected variants (C1C2 wild type, C1C2-N297D, C1C2-N297V, and C1C2-V125L) and correlate them with changes in che… Show more

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Cited by 2 publications
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“…20 For anions such as Cl − , regulation of ion concentration is achieved through membrane transport proteins of the CLC family and others, including channelrhodopsins, which facilitate the passage of Cl − through electro-chemical potential gradients. [25][26][27] While those structurally diverse proteins select for Cl − , other channel proteins discriminate against Cl − . An interesting example is FLUC, a family of fluoride-specific ion channels with dual-topology architecture.…”
Section: Context: Selectivity Of Membrane Ion Channelsmentioning
confidence: 99%
“…20 For anions such as Cl − , regulation of ion concentration is achieved through membrane transport proteins of the CLC family and others, including channelrhodopsins, which facilitate the passage of Cl − through electro-chemical potential gradients. [25][26][27] While those structurally diverse proteins select for Cl − , other channel proteins discriminate against Cl − . An interesting example is FLUC, a family of fluoride-specific ion channels with dual-topology architecture.…”
Section: Context: Selectivity Of Membrane Ion Channelsmentioning
confidence: 99%