Chaotropic Effect-Induced Self-Assembly of the Malachite Green and Boron Cluster for Toxicity Regulation and Photothermal Therapy

Wang, Zi-Xin; Chen, Xiaofang; Liu, Xinyu; Li, Wen-Zhen; Ye, Yu-Yuan; Xu, Shi-Yuan; Zhang, Haibo; Wang, Xiao-Qiang

doi:10.1021/acsami.3c13664

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Therefore, precise control of the light exposure time is crucial for the generation of free radicals. Throughout the reaction, hydrogen peroxide is activated on the surface of the catalyst to become hydroxyl radicals. − The reaction equation is as follows: MB + false[ B 12 H 12 false] 2 − → false[ MB false] − • + false[ B 12 H 12 false] − • false[ MB false] − • + H 2 O 2 → MB + OH • + OH − false[ B 12 H 12 false] − • + H 2 O 2 → false[ B 12 H 13 false] − + OOH • 2 false[ B 12 H 13 false] − + 2 OH − + OOH • → 2 false[…”

Section: Resultsmentioning

confidence: 99%

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Antitumor Therapy through Photothermal Performance Synergized with Catalytic Activity Based on the Boron Cluster Supramolecular Frameworks

Wang,

et al. 2024

ACS Appl. Mater. Interfaces

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Chemodynamic therapy (CDT) has received widespread attention as a tumor optical treatment strategy in the field of malignant tumor therapy. Nonmetallic multifunctional nanomaterials as CDT agents, due to their low toxicity, long-lasting effects, and safety characteristics, have promising applications in the integrated diagnosis and treatment of cancer. Here, we modified the supramolecular framework of boron clusters, coupled with a variety of dyes to develop a series of metal-free agent compounds, and demonstrated that these nonmetallic compounds have excellent CDT activities through experiments. Subsequently, the best performing Methylene Blue/[closo-B 12 H 12 ] 2− (MB@B 12 H 12 ) was used as an example. Through theoretical calculations, electron paramagnetic resonance spectroscopy, and 808 nm light irradiation, we confirmed that MB@B 12 H 12 exhibited photothermal performance and CDT activity further. More importantly, we applied MB@B 12 H 12 to melanoma cells and subcutaneous tumor, demonstrating its effective suppression of melanoma growth in vitro and in vivo through the synergistic effects of photothermal performance and CDT activity. This study emphasizes the generalizability of the coupling of dyes to [closo-B 12 H 12 ] 2− with important clinical translational potential for CDT reagents. Among them, MB@B 12 H 12 may have a brighter future, paving the way for the rapid development of metal-free CDT reagents.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antitumor Therapy through Photothermal Performance Synergized with Catalytic Activity Based on the Boron Cluster Supramolecular Frameworks

Wang,

et al. 2024

ACS Appl. Mater. Interfaces

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“…The chaotropic effect is a new noncovalent interaction that is distinct from hydrogen bonding and electrostatic interactions, and it is beneficial to facilitate the generation and stability of organic radicals. − Closo -dodecaborate cluster (B 12 H 12 2– ), which possesses two permanent negative charges, − is a highly water-soluble suprachaotropic anion capable of self-assembling with positively charged quaternary ammonium derivatives through the chaotropic effect to form stable supramolecular complexes. − N , N ′-dimethylated dipyridinium thiazolo [5,4- d ] thiazole (MPT 2+ ), a water-soluble cationic fluorescent dye, can be reduced to cationic radicals via chemical, photoinduced, or electrostimulation methods . However, the high electrophilicity of radicals makes them short-lived, unstable, and susceptible to reoxidation when exposed to air. − ,− This greatly limits their photothermal therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

Boron Cluster Renders Organic Radicals Water-Stable for Photothermal Anti-Infections

Xiao,

Li,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

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Water-stable organic radicals are promising photothermal conversion candidates for photothermal therapy (PTT). However, organic radicals are usually unstable in biological environments, which greatly hinders their wide application. Here, we have developed a chaotropic effect-based and photoinduced water-stable supramolecular radical (MB12-2) for efficient antibacterial PTT. The supramolecular radical precursor MB12-1 was constructed by the chaotropic effect between closo-dodecaborate cluster (B12H12 2–) and N,N′-dimethylated dipyridinium thiazolo [5,4-d] thiazole (MPT2+). Subsequently, with triethanolamine (TEOA) serving as an electron donor, MB12-1 could transform to its radical form MB12-2 through photoinduced electron transfer (PET) under 435-nm laser irradiation. The N2 adsorption–desorption analysis confirmed that MB12-2 was tightly packed through the introduction of B12H12 2–, which effectively enhanced its stability via a spatial site-blocked effect. Moreover, the half-life of MB12-2 in water was calculated through ultraviolet–visible light (UV-vis) absorption spectra results for periods as long as 20 days. In addition, in the skin infection model, MB12-2, as a wound dressing, showed remarkable photothermal antibacterial activity (>97%) under 660-nm laser irradiation and promoted wound healing. This study presents a simple method for designing long-term water-stable supramolecular radicals, offering a novel avenue for noncontact treatments for bacterial infections.

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Supramolecular Photosensitizer-Loaded Spray Hydrogel for Antibacterial Photodynamic Therapy

Fang,

Wang,

Zhou

et al. 2024

ACS Appl. Polym. Mater.

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Skin is the initial defense against infection of the body but becomes vulnerable when damaged. Subsequent bacterial infections can cause more severe ulcers. Antibiotics are useful for infected wound healing but can also speed up the evolution of antibiotic-resistant bacteria. Dressing and antibacterial photodynamic therapy (PDT) are effective methods for protecting and treating wounds, respectively. Herein, we developed a spray hydrogel based on sodium alginate hydrogels, loaded with methylene blue (MB) and closo-dodecaborate cluster (closo-B 12 H 12 2− ), for physical protection and antibacterial PDT. Among them, MB acted as the photosensitizer, which can produce reactive oxygen species (ROS) through the PDT process to implement the therapeutic effect toward bacterial-infected wounds. closo-B 12 H 12 2− and MB can form a supramolecular photosensitizer (MB-B 12 ), which can reduce the dark toxicity of the MB photosensitizer without significantly affecting its PDT effect. Moreover, the introduction of closo-B 12 H 12 2− can upgrade the physical property of the spray hydrogel for better wound protection and can also increase the MB loading capacity for better wound healing. The hydrogel demonstrated an outstanding antibacterial ability of around 99% against Staphylococcus aureus and 95% for Escherichia coli. This PDT-spray hydrogel system can be a favorable option for protecting and treating bacterial-infected wounds.

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Chaotropic Effect-Induced Self-Assembly of the Malachite Green and Boron Cluster for Toxicity Regulation and Photothermal Therapy

Cited by 3 publications

References 37 publications

Antitumor Therapy through Photothermal Performance Synergized with Catalytic Activity Based on the Boron Cluster Supramolecular Frameworks

Antitumor Therapy through Photothermal Performance Synergized with Catalytic Activity Based on the Boron Cluster Supramolecular Frameworks

Boron Cluster Renders Organic Radicals Water-Stable for Photothermal Anti-Infections

Supramolecular Photosensitizer-Loaded Spray Hydrogel for Antibacterial Photodynamic Therapy

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