Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019

Mafayle, Roxana Loayza; Morales-Betoulle, Maria; Romero, Carla; Cossaboom, Caitlin M.; Whitmer, Shannon; Aguilera, C.; Ardaya, Cinthia Avila; Zambrana, M. Cruz; Anajia, Andrés Dávalos; Loayza, Nelly Mendoza; Montaño, Ana-Maria; Alvis, Fernando L Morales; Guzmán, Jimmy Revollo; Martínez, Sebastián Sasías; Vega, Gricel Alarcón De La; Ramírez, Armando Medina; Gutiérrez, Jhemis T Molina; Pinto, Alex J Cornejo; Bacci, Renata Salas; Brignone, Julia; Garcia, Jorge; Añez, Arletta; Méndez‐Rico, Jairo; Luz, Kléber Giovanni; Segales, Ariel; Cruz, Karen M Torrez; Valdivia-Cayoja, Adolfo; Amman, Brian R.; Choi, Mary J.; Erickson, Bobbie-Rae; Goldsmith, Cynthia S.; Graziano, James; Joyce, Allison; Klena, John D.; Leach, Austin; Malenfant, Jason H; Nichol, Stuart T.; Patel, Ketan; Sealy, Tara K.; Shoemaker, Trevor; Spiropoulou, Christina F.; Todres, Alison M.; Towner, Jonathan S.

doi:10.1056/nejmoa2110339

Cited by 21 publications

(17 citation statements)

References 26 publications

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“…There is a low number of documented CHHF cases, which limits understanding of symptom progression and stages of this illness. Infectivity is hypothesized to result from a zoonotic reservoir (potentially O. microtis, although further investigation is needed) or human-tohuman contact (17). Discovery of the virus was associated with a small outbreak of severe hemorrhagic fever in Bolivia in 2003 (18).…”

Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

“…CHAPV RNA was detected using RT-PCR in conjunctiva, along with other human body fluid samples, including blood, urine, nasopharyngeal, oropharyngeal, and semen (17). No specific ophthalmic symptoms associated with CHHF have been reported.…”

Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

“…Reported symptoms of CHAPV include fever, upper gastrointestinal hemorrhage and acute respiratory distress syndrome (ARDS) (19,20). Although the presentation of CHHF may be similar to other endemic agents such as dengue and Bolivian hemorrhagic fever in the absence of molecular testing, a defining feature of CHHF may be continuation of fever, myalgia, weakness, or neurologic symptoms with hemorrhagic manifestations persisting more than seven days after symptom onset (17). The specific mechanism of CHAPV pathogenesis is not clearly defined, although postulated mechanisms of arenavirus infectivity include factors that increase viral replication capacity and suppression of the host's innate immunity leading to severe hemorrhagic disease (21).…”

Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

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Ophthalmic consequences of viral hemorrhagic fevers: Insights from the clinic and laboratory

Karnam

Huang²,

Yeh³

2023

Front. Trop. Dis

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Viral hemorrhagic fevers (VHFs) are a diverse group of RNA virus-mediated systemic diseases with significant morbidity and mortality and represent a significant public health concern. Given the high systemic morbidity and mortality in a number of these entities, delays in diagnosis can lead to downstream public health consequences. Many viral hemorrhagic fevers have ophthalmic manifestations and ophthalmologists thus play a key role in disease recognition and the management of ocular complications associated with specific hemorrhagic fevers. This review summarizes the key ophthalmic consequences of viral hemorrhagic fevers, viral disease pathogenesis, disease findings, and areas of unmet research need.

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Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

Section: Chapare Hemorrhagic Fevermentioning

confidence: 99%

See 1 more Smart Citation

Ophthalmic consequences of viral hemorrhagic fevers: Insights from the clinic and laboratory

Karnam

Huang²,

Yeh³

2023

Front. Trop. Dis

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

“…In concordance, two viral infections, Chapare hemorrhagic fever [ 3 ] and Marburg virus disease [ 4 ], highlighted in recent publications, have both been closely associated with semen and have the possibility of sexual transmission. Chapare virus [ 3 ] was observed in the semen of a patient 86 days after symptom onset. Despite not testing for Marburg virus [ 4 ] in the semen, there is evidence that it persists in the testes of nonhuman primates and disrupts the blood-testis barrier [ 5 ].…”

mentioning

confidence: 99%