2017
DOI: 10.1080/21624054.2017.1371403
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Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity

Abstract: The integrity of the cellular proteome is supported by quality control networks, which govern protein synthesis, folding, and degradation. It is generally accepted that an age-related decline in protein homeostasis (proteostasis) contributes to protein aggregation diseases. However, the mechanistic principles underlying proteostasis imbalance and the impact on life expectancy are not well understood. We recently demonstrated that this interrelation is affected by chaperone-directed ubiquitylation, shifting the… Show more

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