Chapter 1.1 Anatomy and function of extrahypothalamic vasopressin systems in the brain

Vries, Geert J. De; Ma, Miller

doi:10.1016/s0079-6123(08)61558-7

Cited by 169 publications

(105 citation statements)

References 85 publications

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“…The central and behavioral affects of AVP are likely a result of other AVP systems in the brain. There exists a sexually dimorphic extrahypothalamic AVP circuit that may play a critical role in AVP-mediated behavior (de Vries and Miller, 1998). In this circuit, AVP is synthesized in the medial amygdala and the bed nucleus of the stria terminalis and AVP neurons from these areas project to forebrain structures such as the lateral septum.…”

Section: Discussionmentioning

confidence: 99%

“…In this circuit, AVP is synthesized in the medial amygdala and the bed nucleus of the stria terminalis and AVP neurons from these areas project to forebrain structures such as the lateral septum. The lateral septum contains a dense plexus of fibers containing AVP (de Vries and Miller, 1998). Lesions of the lateral septum reduce anxiety-related behavior and septally released AVP has been shown to be causally involved in social recognition and anxiety-related behavior (Menard and Treit, 1996;Landgraf et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Given the role of AVP in suparchiasmatic nucleus (SCN) functioning (de Vries and Miller, 1998) it is possible that some of our behavioral effects could be attributable to changes in circadian rhythm, particularly the anxiety tests, which are based on the animals' natural aversion to bright light. Such an indirect effect cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Bielsky

Szegda

et al. 2003

Neuropsychopharmacol

476

338

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“…[37][38][39][40][41] Chemosensory cues are transmitted from the main olfactory epithelium and volmeronasal epithelium to neurons in these brain regions where they are processed so that the appropriate behavioral response can be determined. [37][38][39][40][41] The MA and BNST both contain VP immunoreactivity [42][43][44] and V1aR binding and transcripts, [45][46][47] and V1bR immunoreactivity. 33 Aggressive behavior is correlated with VP immunoreactivity in fibers in the lateral septum (whose VP cell bodies are located in the BNST).…”

Section: Discussionmentioning

confidence: 99%

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoring the need for a better understanding of the neural bases of aggression. Vasopressin, acting through its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much less attention due to a lack of specific drugs. Here we report that mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition. By contrast, they perform normally in all the other behaviors that we have examined, such as sexual behavior, suggesting that reduced aggression and social memory are not simply the result of a global deficit in sensorimotor function or motivation. Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain. We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries. Molecular Psychiatry (2002) 7, 975-984.

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“…Behavioral differences between male and female rodents in social recognition memory rely in part on sexually dimorphic neural pathways, including the extrahypothalamic systems of the neuropeptides arginine-vasopressin and oxytocin [4,5]. For instance, the density of vasopressinergic projections from the bed nucleus of the stria terminalis (BNST) and the medial amygdala to the lateral septum is greater in males compared to females [6].…”

Section: Introductionmentioning

confidence: 99%

Social recognition memory: Influence of age, sex, and ovarian hormonal status

Markham

Juraska

2007

Physiology & Behavior

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Social recognition memory underlies many forms of rodent interaction and can be easily tested in the laboratory. Sex differences in aspects of this memory have been reported among young adults, and some studies indicate an age-related decline among male rats. In contrast, neither the impact of natural fluctuations in ovarian hormones nor the performance of aged female rats on social recognition memory has been previously evaluated. In experiments 1 and 2, the social recognition memory of young adult female Long-Evans rats (age 3-5 mos.) was compared during proestrus and estrus, and performance was found to be stable across estrous cycle phases. In experiment 3, the social recognition memory of young adults as compared to aged (16.5-19.5 mos.) rats was tested using the social discrimination procedure, following delays of 15, 45, 90 or 120 minutes. The estropausal status of aged female rats was tracked during the experiment but was not found to influence memory ability. Males of both ages investigated juveniles (both novel and familiar) more than did females, although despite this difference, both sexes demonstrated robust memory. Interestingly, only young adult females were capable of demonstrating memory following the longest delay. Collectively, our findings indicate that the pattern of age-related changes in social recognition memory is subtle and that aging does not greatly alter the behavioral sex differences observed among young adults.

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Chapter 1.1 Anatomy and function of extrahypothalamic vasopressin systems in the brain

Cited by 169 publications

References 85 publications

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Social recognition memory: Influence of age, sex, and ovarian hormonal status

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