Chapter 1 The cellular framework for chemical signalling in the nucleus accumbens

Meredith, Gloria E.; Pennartz, Cyriel M. A.; Groenewegen, Henk J.

doi:10.1016/s0079-6123(08)61335-7

Cited by 178 publications

(127 citation statements)

References 102 publications

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“…METH, 2.5 mg/kg, induced sustained elevation in locomotor activity and this effect lasted for at least 60 min. A dose of 0.3125 mg/kg of METH had no effect while 2.5 mg/kg of the drug caused a maximal response during the entire 120 min period of testing (F [7,32] = 21.84, P < 0.001; Fig. 2D).…”

Section: Dose Effects Of Acute Injection Of Meth On Locomotor Activitmentioning

confidence: 96%

“…The behavioral activating effects of AMPH are thought to depend primarily on its ability to increase dopamine release in the terminal regions of the mesoaccumbens and neostriatum [16]. In addition, by regulating dopamine release in the midbrain, glutamate also plays an important role in regulation of motor activity [32]. Therefore, the majority of studies related to behavioral sensitization were focused on dopaminergic and glutamatergic systems.…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Chiu

2005

Brain Research Bulletin

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Repeated intermittent exposure to psychostimulants was found to produce behavioral sensitization. The present study was designed to establish a mouse model and by which to investigate whether opioidergic system plays a role in methamphetamine-induced behavioral sensitization. Mice injected with 2.5 mg/kg of methamphetamine once a day for 7 consecutive days showed behavioral sensitization after challenge with 0.3125 mg/kg of the drug on day 11, whereas mice injected with a lower daily dose (1.25 mg/kg) did not. Mice received daily injections with either 1.25 or 2.5 mg/kg of methamphetamine showed behavioral sensitization after challenge with 1.25 mg/kg of the drug on days 11, 21, and 28. To investigate the role of opioidergic system in the induction and expression of behavioral sensitization, long-acting but non-selective opioid antagonist naltrexone was administrated prior to the daily injections of and challenge with methamphetamine, respectively. Our results show that the expressions of behavioral sensitization were attenuated by pretreatment with 10 or 20 mg/kg of naltrexone either during the induction period or before methamphetamine challenge when they were tested on days 11 and 21. These results indicate that repeated injection with methamphetamine dose-dependently induced behavioral sensitization in mice, and suggest the involvement of opioid receptors in the induction and expression of methamphetamine-induced behavioral sensitization.

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Section: Dose Effects Of Acute Injection Of Meth On Locomotor Activitmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Chiu

2005

Brain Research Bulletin

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“…Both hippocampal and amygdaloid terminals in the Nacb make asymmetrical synapses, primarily on dendritic spines (Totterdell and Smith, 1989;Kita and Kitai, 1990;Meredith et al, 1993;Johnson et al, 1994). An examination of the typical polarity of the field generated by EPSPs in the Nacb, i.e., positive after Fo/Fi stimulation and negative after BLA stimulation, and the coincidence of unit firing with these fields allow us to make some suggestions about the possible distribution of synaptic inputs.…”

Section: Termination Patterns Of Amygdalar and Hippocampal Afferents mentioning

confidence: 99%

Electrophysiology of the Hippocampal and Amygdaloid Projections to the Nucleus Accumbens of the Rat: Convergence, Segregation, and Interaction of Inputs

1998

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The nucleus accumbens (Nacb) receives inputs from hippocampus and amygdala but it is still unclear how these inputs are functionally organized and may interact. The interplay between these input pathways was examined using electrophysiological tools in the rat, in vivo, under halothane anesthesia. After fornix/fimbria stimulation (Fo/Fi, subicular projection fibers to the Nacb), mono-and polysynaptically driven single units were recorded in the medial shell/core regions of the Nacb and in the ventromedial caudate putamen. Monosynaptically driven neurons by basolateral amygdala (BLA) stimulation were found in the medial shell/core and in the ventrolateral shell/core regions. In the areas of convergence (medial shell/core), paired activation of BLA followed by that of Fo/Fi resulted in an enhancement of the Fo/Fi response, whereas stimulation in the reverse order, Fo/Fi followed by BLA, led to a depression of the BLA response. In addition to these patterns of interactions, the tetanization of the Fo/Fi to Nacb pathway caused a homosynaptic decremental (long-term) potentiation in the Nacb, accompanied by a heterosynaptic (long-term) depression of the nontetanized BLA to Nacb pathway. We postulate that the hippocampal inputs may close a "gate" for the amygdala inputs, whereas the gate is opened for the hippocampus inputs by previous amygdalar activity. These opposite effects on the Nacb neuronal populations should be taken into account when interpreting behavioral phenomena, particularly with respect to the contrasting effects of the amygdala and the hippocampus in locomotion and place learning.

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“…While the NAcc constitutes the major subcortical terminal field of DA perikarya located in the ventral tegmental area, it also receives extensive glutamatergic projections directly from the prefrontal cortex and limbic structures such as the hippocampal formation and amygdala (Christie et al, 1987;Meredith et al, 1993). These structures have been implicated in the reinstatement of drug seeking by drug-paired stimuli (amygdala and hippocampus; Grimm and See, 2000;Vorel et al, 2001) and cocaine (prefrontal cortex; Park et al, 2002;McFarland et al, 2003) as have their glutamatergic projections to the NAcc.…”

Section: Introductionmentioning

confidence: 99%

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Suto

Tanabe

Austin

et al. 2004

Neuropsychopharmacol

103

100

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The effect of previous exposure to psychostimulants on the subsequent self-administration of cocaine as well as reinstatement of this behavior by priming infusions of AMPA into the nucleus accumbens (NAcc) was examined. Rats were exposed to five injections, one injection every third day, of either saline or amphetamine (AMPH: 1.5 mg/kg, i.p.). Starting 10 days later, they were trained to selfadminister cocaine (0.3 mg/kg/infusion, i.v.) and subsequently tested under a progressive ratio (PR) schedule for 4 consecutive days. As expected, rats exposed to AMPH worked more and obtained more cocaine infusions than saline exposed controls on the PR test sessions. Following daily extinction sessions during which saline was substituted for cocaine, the effect of priming infusions of AMPA (0.0, 0.08, or 0.8 nmol/0.5 ml/side) into the NAcc was then examined on two tests: one conducted 4 days after the last cocaine PR test session (2-3 weeks after the last AMPH exposure injection) and the next 4 weeks later. Consistent with previous reports, NAcc AMPA dosedependently reinstated cocaine seeking on both tests regardless of exposure condition. Importantly, this priming effect of NAcc AMPA was significantly enhanced in AMPH compared to saline exposed rats on the first test conducted 2-3 weeks after AMPH. On the second test, conducted 4 weeks after cocaine, reinstatement was similarly enhanced in both groups to levels observed on the first test in AMPH exposed rats. These results indicate that both noncontingent (AMPH) and contingent (cocaine) exposure to psychostimulants enhances the reinstatement of cocaine seeking by NAcc AMPA and appears to do so in a time-dependent manner.

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Chapter 1 The cellular framework for chemical signalling in the nucleus accumbens

Cited by 178 publications

References 102 publications

Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Attenuation of methamphetamine-induced behavioral sensitization in mice by systemic administration of naltrexone

Electrophysiology of the Hippocampal and Amygdaloid Projections to the Nucleus Accumbens of the Rat: Convergence, Segregation, and Interaction of Inputs

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

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