Chapter 1 Tropolonic Colchicum Alkaloids

Capraro, Hans‐Georg; Brossi, Arnold

doi:10.1016/s0099-9598(08)60069-3

Cited by 56 publications

(81 citation statements)

References 182 publications

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“…[1][2][3] The extract from the plants containing this compound has been well known for ages as a medicine against gout as first described in De Materia Medica by Pedanius Dioscorides. 4 Colchicine can efficiently alleviate the symptoms during gout attacks when applied in the early phase because of its anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometric study of colchicine and its synthetic derivatives 10-alkylthiocolchicines

Kurek

Nowakowska

Bartkowiak

2015

ACSi

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The mass spectra behaviour of five 10-alkylthiocolchicine derivatives has been studied using electron ionization and MALDI-TOF MS techniques. Fragmentation patterns of colchicines derivatives after EI have been investigated, as well as mass spectra after collision-induced dissociation (CID) MALDI have been used to gain structural information. To the best of our knowledge, this is the first time that the MALDI MS/MS data for colchicine and its alkylthio derivatives have been described. It has been shown also that the data derived from mass spectra can be used for identification/quantitative determination of natural and modified alkaloids of colchicine group. The detailed fragmentation pathways proposed here could be helpful for the characterization of other colchicines of these type. The utility of different ionization techniques for analysis of compounds of this class has been evaluated. Due to the cytotoxic activity towards tumour cell lines, 10-alkylthiocolchicines may be considered as the active ingredients of anticancer agents. If these compounds find use in medical treatment, their distribution in organism and their metabolism will have to be monitored by spectroscopic or spectrometric methods. The characteristic fragment ions may be used by Selected Reaction Monitoring method for determination of colchicine analogues.

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Section: Introductionmentioning

confidence: 99%

Mass spectrometric study of colchicine and its synthetic derivatives 10-alkylthiocolchicines

Kurek

Nowakowska

Bartkowiak

2015

ACSi

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“…The main degradation products described are -and -lumi colchicines and colchiceines (Capraro & Brossi, 1984;Körner & Kohn, 2005).…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Pırıldar

Sütlüpınar

Atasever

et al. 2009

Pharmaceutical Biology

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“…[21,22] The tubers contain colchicines, benzoic and salicylic acid, sterols and resinous substances-colchicines, 3-demethyl colchicine, 1,2-didemethyl colchicine, 2,3-didemethyl colchicine, N-formyl, N-deacetyl colchicines, colchicocide, gloriosine, tannins and superbine. [23] In the world market they are considered as rich sources of colchicines and gloriosine. [24,25] In carrying out this study, the aim was to evaluate in vitro the antimicrobial potency of V. nugundo and G. superba by investigating the sensitivities of known pathogenic bacteria, Escherichia coli, Salmonella typhi, Staphylococcus aureus and Candida albicans, to the plant leaf extracts, individually and in combination with themselves and with a known antibiotic.…”

Section: Preparation Of Extract Concentrations For Minimum Inhibitorymentioning

confidence: 99%

Assessment of the Antimicrobial Potency of Leaf Extracts from Vitex Nugundo and Gloriosa Superba

Choudhary¹,

Mathur²,

Chaudhary

et al. 2011

Pharmacognosy Journal

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a B S t r a c t an increase in the number of antibiotic resistant strains makes the discovery of new therapeutic agents critically important. During present study antimicrobial effects of the leaf extracts of Vitex nugundo (Vn) and Gloriosa superba (gS) in combination with chloramphenicol, on Escherichia coli, Salmonella typhi, Staphlococcus aureus and Candida albicans was investigated. For this purpose, the dilution sensitivity and disc diffusion techniques were respectively applied in determining minimum inhibitory concentration (Mic) of the plant extracts, and the sensitivities of the organisms to the plant extracts and their combinations with chloramphenicol. V. nugundo and G. superba showed very high antimicrobial activity against all the test organisms. in combination, the effect of Vn on E. coli and S. typhi was completely antagonized by that of gS whereas additive effect on S. aureus and C. albicans was observed, indicating that the combination of Vn and gS might be effective against gram positive pathogenic organisms. the combination of either plant extract with chloramphenicol produced synergistic effect on only C. albicans. the smaller Mic of gS indicated greater effectivity than Vn. it is concluded that the additive effect produced by the combination of the two plant extracts, and the synergic effect from the combination of any of the extracts with chloramphenicol, offer alternative therapy to gram positive bacterial infections and candidiasis respectively.

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Chapter 1 Tropolonic Colchicum Alkaloids

Cited by 56 publications

References 182 publications

Mass spectrometric study of colchicine and its synthetic derivatives 10-alkylthiocolchicines

Mass spectrometric study of colchicine and its synthetic derivatives 10-alkylthiocolchicines

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Assessment of the Antimicrobial Potency of Leaf Extracts from Vitex Nugundo and Gloriosa Superba

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