Chapter 10. Pulmonary and Antiallergy Agents

Musser, John H.; Kreft, Anthony F.; Lewis, Alan J.

doi:10.1016/s0065-7743(08)60686-7

Annual Reports in Medicinal Chemistry

1984

DOI: 10.1016/s0065-7743(08)60686-7

|View full text |Cite

Chapter 10. Pulmonary and Antiallergy Agents

John H. Musser¹,

Anthony F. Kreft²,

Alan J. Lewis³

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1985

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We were not able to prepare norlysergic acid N,N-diethylamide following the method of Niwaguchi et al 2,3 The failure occurred in attempts to remove the iV(6)-cyano group. Although base hydrolysis afforded an N(6)-carbamoyl derivative, as reported, this resisted repeated attempts at conversion to norlysergic acid IV/IV-diethylamide using dilute nitrous acid and a variety of reaction conditions.…”

mentioning

confidence: 99%

Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives

Hoffman¹,

Nichols²

1985

J. Med. Chem.

View full text Add to dashboard Cite

A convenient method for the synthesis of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives was developed. A series of these compounds was synthesized and tested for substitution in the two-lever drug discrimination assay, in rats trained to discriminate injections of d-LSD tartrate (185.5 nmol/kg, ip) from saline. A dose-response curve for each of the compounds in the series was generated. Structure-activity relationships were developed, based on comparison of the estimated ED50 values from these curves. Of the compounds that substituted for LSD, the N(6)-ethyl and -allyl were approximately 2-3 times more potent than LSD itself. The N(6)-propyl was equipotent to LSD, while the isopropyl derivative was half as active. The n-butyl compound was 1 order of magnitude less potent than LSD, suggesting a similarity to the SAR of certain serotonin and dopamine agonists. By contrast, no generalization occurred to norlysergic acid N,N-diethylamide and the N(6)-2-phenethyl derivative.

show abstract

mentioning

confidence: 99%

Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives

Hoffman¹,

Nichols²

1985

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Chapter 10. Pulmonary and Antiallergy Agents

Cited by 1 publication

References 140 publications

Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives

Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives

Contact Info

Product

Resources

About