Chapter 13. Antifungal Chemotherapy

Gravestock, Michael B.; Ryley, John F.

doi:10.1016/s0065-7743(08)60689-2

Cited by 17 publications

(6 citation statements)

References 54 publications

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“…The antifungal activity 17 was assayed by sabouraud dextrose agar media plate disc diffusion method at the concentration of 50 µg per disk. All the synthesized compounds were tested in vitro for their antifungal activity against microorganisms such as Asperagellus niger (NCIM 618) and Candida albicans (NCIM 3557).…”

Section: Antifungal Activitymentioning

confidence: 99%

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

Singh

Hashim

Singhal

2010

Journal of Chemistry

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2-Chloro-3-methylquinoxaline was selected as nucleus around which the molecular manipulations were carried out to get new compounds expected to possess better anti microbial activity. Various quinoxaline derivatives have been synthesized by replacing the chlorine at C-2 with a thioether linkage, which in turn attached to 2-(N-(substituted phenyl)acetamides. The synthesized compounds (5) were tested for their antimicrobial activity. Compounds 5b, 5c, 5d and 5i were found most active (comparable to the standard antibacterial Ciprofloxacin) amongst them. The structure of the compounds was confirmed on the basis of their spectral data.

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Section: Antifungal Activitymentioning

confidence: 99%

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

Singh

Hashim

Singhal

2010

Journal of Chemistry

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“…In contrast to the vast and rich chemistry of the quiñones, the chemistry of their thione analogues remains practically unexplored.1,2 Although the first futile attempt to synthesize p-dithiobenzoquinone (1) was reported in s s 2 3 1 1909,3 this highly labile molecule was successfully generated only in 1983 using a flash pyrolysis reaction; it was studied spectroscopically in a frozen argon matrix, but it was observed to decompose in an unknown manner, on moderate warming of the matrix.4 The isomeric o-dithiobenzoquinone (2) has proven to be even more elusive.…”

mentioning

confidence: 99%

Thioquinones. A reinvestigation of Perkin and Green's diaminodithioquinone

Lakshmikantham¹,

Raasch²,

Cava³

et al. 1987

J. Org. Chem.

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“…The antifungal activity [ 19 ] was assayed by the Sabouraud dextrose agar media plate disc diffusion method at a concentration of 50 µg per disk. All the synthesized compounds were tested in vitro for their antifungal activity against microorganisms such as Aspergillus niger and Candida albicans .…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

et al. 2010

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2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a–e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a–e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.

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Chapter 13. Antifungal Chemotherapy

Cited by 17 publications

References 54 publications

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

Synthesis and Antimicrobial Activity ofSome New Thioether Derivatives of Quinoxaline

Thioquinones. A reinvestigation of Perkin and Green's diaminodithioquinone

Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

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