Indigenous communities are actively engaged in interdisciplinary climate adaptation initiatives across the United States making them experienced witnesses to community-based adaptation. This study offers the results of a regional survey of climate information and data needed to enhance the climate resiliency of water resources on reservation lands in the arid southwestern United States. Regional studies of this nature are particularly rare—and reasonably so—due to the place-based nature of Indigenous cultures and the diversity of community experiences. Study participants include tribal government employees, agriculturalists, researchers, and outreach professionals actively engaged in climate adaptation and resiliency efforts on reservation lands. Study respondents prioritize climate information and data that serve to assess local climate change impacts, enhance food security, and integrate the traditional knowledge of their communities into reservation-wide climate adaptation initiatives. In this arid and predominantly rural region, respondents prioritize water quality data as their highest need followed by streamflow data and air temperature data. They most frequently access their respective tribal sources of climate information and data. This research utilizes a participatory approach to identify needs unique to reservation lands in the southwestern United States while illuminating the critical role of Indigenous sovereignty in enhancing climate resiliency.