CHAPTER 16. Dry Powder Coating of Pharmaceutical Solid Dosages

Zhu, Jesse; Jing, Zhehao; Yang, Qingliang; Ma, Yingliang; Chow, Kwok; Shi, Kaiqi

doi:10.1039/9781788012997-00395

Cited by 2 publications

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“…Compared to other dry coating technologies, electrostatic dry powder coating has possibly gained more attention due to its distinguished advantages, such as being highly valued for energy savings and significant reduction of overall operation cost. Most importantly, electrostatic powder coating is capable of being applied for most of the commercialized coating polymers without any selectivity, which make it promising as a green alternative to organic solvent coating or aqueous coating [80].…”

Section: Discussionmentioning

confidence: 99%

An Update of Moisture Barrier Coating for Drug Delivery

Yang

Feng

et al. 2019

Pharmaceutics

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Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages. Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from hydrolytic degradation during the manufacturing process and storage. Coating formulation design and process control are the two most commonly used strategies to reduce water vapor permeability to achieve the moisture barrier function. The principles of formulation development include designing a coating formulation with non-hygroscopic/low water activity excipients, and formulating the film-forming polymers with the least amount of inherent moisture. The coating process involves spraying organic or aqueous coating solutions made of natural or synthetic polymers onto the surface of the dosage cores in a drum or a fluid bed coater. However, the aqueous coating process needs to be carefully controlled to prevent hydrolytic degradation of the drug due to the presence of water during the coating process. Recently, different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film. Those strategies include newly designed coating formulations containing polymers with optimized functionality of moisture barrier, and newly developed dry coating processes that eliminate the usage of organic solvent and water, and could potentially replace the current solvent and aqueous coatings. This review aims to summarize the recent advances and updates in moisture barrier coatings.

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Section: Discussionmentioning

confidence: 99%

An Update of Moisture Barrier Coating for Drug Delivery

Yang

Feng

et al. 2019

Pharmaceutics

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A review on applications of fine particles integrated with fluidization technologies

Song,

Yuan,

Zhu

2024

Can J Chem Eng

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Fine particles possess remarkable characteristics including extensive surface‐to‐weight ratios and diverse morphologies. Consequently, through the use of fluidization techniques, they have become favoured in various industrial processes, especially with continuous production. This review paper offers a comprehensive exploration of the integration of fine particle applications with fluidization technologies, with a specific focus on the Geldart Group C particles sized <25–40 μm. Although there are challenges with processing fine particles such as the strong cohesion in fluidized beds, recent progress, including the nanoparticle modulation method, has demonstrated potential solutions. These advancements render these cohesive particles applicable to industrial applications in different fields, including gas‐phase catalytic reactions, gas–solid fluidized bed coal beneficiation, ultrafine powder coating (UPC), pharmaceuticals, environmental sustainability, energy storage, and food processing. However, further research is needed to obtain a better understanding of fine particle fluidization in industrial settings in order to achieve larger‐scale implementation. In summary, this review provides a comprehensive overview of fine particle utilization integrated with fluidization technologies, demonstrating the potential in large‐scale industrial processes, and enabling significant advancements in practical applications.

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CHAPTER 16. Dry Powder Coating of Pharmaceutical Solid Dosages

Cited by 2 publications

References 0 publications

An Update of Moisture Barrier Coating for Drug Delivery

An Update of Moisture Barrier Coating for Drug Delivery

A review on applications of fine particles integrated with fluidization technologies

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