Chapter 2 Subcortical Ischemic Cerebrovascular Dementia

Menon, Uma; Kelley, Roger E.

doi:10.1016/s0074-7742(09)00402-4

Cited by 26 publications

(14 citation statements)

References 67 publications

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“…Previous results from clinical imaging and molecular studies have suggested a link between CVRF, structural deformities of brain microvessels (including arterial stiffness and microvascular damage), and the risk of dementia (Bell et al 2009;Grammas 2011a). Chronic cerebral blood flow deficits secondary to conditions such as diabetes, hypertension, and atherosclerosis, as well as heart failure-related microembolism, may all lead to decreased oxygen and glucose supply to the brain, as well as local toxic or metabolic disturbances (KumarSingh 2008;Bangen et al 2009;Menon and Kelley 2009). It has been suggested that microvascular changes secondary to chronic cerebral blood flow reductions might trigger the characteristic neuropathological changes of AD, such as aggregates of amyloid β-peptide (de la Torre 1999; de la Torre et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations

Tamashiro-Duran

Squarzoni

Duran

et al. 2012

AGE

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Cardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented AGE (2013) 35:777-792 DOI 10.1007 Electronic supplementary material The online version of this article (doi:10.1007/s11357-012-9413-y) contains supplementary material, which is available to authorized users. carriers of the apolipoprotein ε4 (APOE ε4) allele, the major genetic risk factor for AD. However, functional neuroimaging studies investigating the impact of CVRF on cerebral metabolism have been scarce to date. The present FDG-PET study investigated 59 cognitively preserved elderlies divided into three groups according to their cardiovascular risk based on the Framingham 10-year risk Coronary Heart Disease Risk Profile (low-, medium-, and high-risk) to examine whether different levels of CVRF would be associated with reduced CMRgl, involving the same brain regions affected in early stages of AD. Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE ε4 allele as a confounding covariate. Significant cerebral metabolism reductions were detected in the high-risk group when compared to the low-risk group in the left precuneus and posterior cingulate gyrus. This suggests that findings of brain hypometabolism similar to those seen in subjects with AD can be detected in association with the severity of cardiovascular risk in cognitively preserved individuals. Thus, a greater knowledge about how such factors influence brain functioning in healthy subjects over time may provide important insigths for the future development of strategies aimed at delaying or preventing the vascular-related triggering of pathologic brain changes in the AD.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations

Tamashiro-Duran

Squarzoni

Duran

et al. 2012

AGE

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“…Subcortical vascular dementia (SVaD) is considered one of the most common types of vascular dementia and often develops in a slowly progressive manner, similar to Alzheimer's disease dementia (AD) [1][2][3]. Subcortical vascular mild cognitive impairment (svMCI) is a more recently defined condition, thought to represent a prodromal stage of SVaD [4,5], with parallels to amnestic mild cognitive impairment (aMCI) as a prodromal stage of AD.…”

Section: Introductionmentioning

confidence: 99%

The Role of Cerebrovascular Disease in Amyloid Deposition

Noh

Seo

Jeon

et al. 2016

JAD

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“…These aspects have permitted the design of a framework of putative morphological substrates of vascular dementia [2,3,[5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Cognitive impairment of vascular origin: Neuropathology of cognitive impairment of vascular origin

Ferrer

2010

Journal of the Neurological Sciences

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Chapter 2 Subcortical Ischemic Cerebrovascular Dementia

Cited by 26 publications

References 67 publications

Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations

Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations

The Role of Cerebrovascular Disease in Amyloid Deposition

Cognitive impairment of vascular origin: Neuropathology of cognitive impairment of vascular origin

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