2008
DOI: 10.1016/s0065-2660(07)00003-x
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Chapter 3 Evolution of Cis‐Regulatory Sequences in Drosophila

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Cited by 11 publications
(9 citation statements)
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“…Microsatellite repeats, especially (CT)n motifs, exist in abundance in the 5′-UTRs of several eukaryotic genes (Bhattacharyya et al, 2004;Mohammadparast et al, 2014;Zhao et al, 2014). The microsatellites are present in the vicinity of TSSs, indicating that they are likely involved in regulating target gene transcription (Castillo-Davis, 2005;Simpson and Ayyar, 2008). Our first goal was to investigate the highly polymorphic CT repeat located in the core promoter of the LvIRF-5'-UTR.…”
Section: Discussionmentioning
confidence: 99%
“…Microsatellite repeats, especially (CT)n motifs, exist in abundance in the 5′-UTRs of several eukaryotic genes (Bhattacharyya et al, 2004;Mohammadparast et al, 2014;Zhao et al, 2014). The microsatellites are present in the vicinity of TSSs, indicating that they are likely involved in regulating target gene transcription (Castillo-Davis, 2005;Simpson and Ayyar, 2008). Our first goal was to investigate the highly polymorphic CT repeat located in the core promoter of the LvIRF-5'-UTR.…”
Section: Discussionmentioning
confidence: 99%
“…Enhancers that pattern the early Drosophila embryo have been one of the best models for studying the evolution of cis-regulatory sequences because they have well-defined functions under specific conditions (Simpson and Ayyar 2008). However, there is some uncertainty as to whether the results from these early-acting developmental enhancers can be generalized to other cis-regulatory sequences and other species.…”
Section: Discussionmentioning
confidence: 99%
“…This paper considers functional diversity, but this will be only one of several factors associated with animal complexity. Amongst others, an increasing diversity in cis-acting regulatory elements (CAREs) across a phylogeny will play a role 4 5 28 and there may also be a contribution to complexity from changes to the complement of regulatory non-coding RNAs, including the miRNAs 29 30 and lncRNAs that have been shown to modulate gene expression 31 .…”
Section: Discussionmentioning
confidence: 99%