Entrepreneurship has been globally identified as an important factor for economic development. The importance of entrepreneurship has encouraged policymakers to invest in entrepreneurship development, and entrepreneurial mindset and culture are being assumed as important factors to consider in developing entrepreneurship success and growth. This study focused on the role of entrepreneurial mindset and culture on the entrepreneurship success or failure in South Africa. The objective of this study was to understand whether entrepreneurship culture can enhance entrepreneurial mindset and whether both entrepreneurial mindset and culture enhance entrepreneurship success and development. A qualitative research approach was used for this study, where a systematic literature review was followed as the method of review. Various online databases and peer-reviewed journal articles were used in analysing appropriate and relevant literature. The findings revealed that culture and mindset have a robust contribution towards entrepreneurship development and success. The findings further revealed that entrepreneurship culture makes an important contribution to the development of an entrepreneurial mindset, which encourages entrepreneurial intentions and venture success. This study indicates that the creation of an entrepreneurial mindset that drives creativity and innovation, resulting in new ventures being created and entrepreneurship culture being cemented, is very important in encouraging entrepreneurship growth and success.