Chapter 3. Oxidative DNA Damage and Repair in G-quadruplexes

Fleming, Aaron M.; Redstone, Samuel C.; Burrows, Cynthia J.

doi:10.1039/9781839160769-00061

Cited by 2 publications

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“…Fleming et al, in recent studies [127][128][129], have suggested that • OH is not involved in DNA damage caused by oxidative stress and argue that CO3 •− plays a key role in attacking guanine residues in DNA to form 8OHdG, causing in vivo oxidative damage to DNA. However, Halliwell's group examines these claims and concludes that • OH plays a key role and is an important member of reactive oxygen species (ROS) in vivo [130].…”

Section: Co3mentioning

confidence: 99%

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Chemical Insights into Oxidative and Nitrative Modifications of DNA

Andrés,

Lastra,

Juan

et al. 2023

IJMS

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This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and nitrating species, and it may play an important role in the pathophysiology of inflammation, cancer, and degenerative diseases. Infection and chronic inflammation have been recognized as important factors in carcinogenesis. Under inflammatory conditions, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative DNA lesions, such as 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine. Cellular DNA is continuously exposed to a very high level of genotoxic stress caused by physical, chemical, and biological agents, with an estimated 10,000 modifications occurring every hour in the genetic material of each of our cells. This review highlights recent developments in the chemical biology and toxicology of 2′-deoxyribose oxidation products in DNA.

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Section: Co3mentioning

confidence: 99%

“…Fleming et al, in recent studies [127][128][129], have suggested that • OH is not involved in DNA damage caused by oxidative stress and argue that CO 3…”

Section: Comentioning

confidence: 99%