Chapter 32 Development of Stimulus—Secretion Coupling in Salivary Glands

Cutler, Leslie S.; Christian, Constance; Bottaro, Brian

doi:10.1016/s0091-679x(08)61518-6

Cited by 23 publications

(19 citation statements)

References 44 publications

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“…At about the same time, the first secretory proteins are detectable by cytochemical, immunocytochemical, and biochemical procedures (Yamashina and Barka, 1973;Ball, 1974a;Denny et al, 1989;Moreira et al, 1990;Ball et al, 1991. In the parotid gland, development is slower, with secretion granules first appearing one day after birth (Redman and Sreebny, 1971 (Cutler and Rodan, 1976), and becomes progressively responsive to P-adrenergic stimuli between one and six days post partum, due to the increase in receptor density (Cutler et al, 1981). This increase was found to parallel the ingrowth of sympathetic nerve fibers during this time period, suggesting the stimulation of receptor production by the nerves (Bottaro and Cutler, 1984;Cutler et al, 1985).…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

“…(3) SECRETORY PROTEINS OF TYPE III CELLS The Type III cells of rats and proacinar cells of mice are positive for secretory peroxidase reactivity in the fetus and neonate, and they secrete it upon l-adrenegic stimulation (Strum, 1971, Yamashina andBarka, 1974;Cutler et al, 1981;Denny et al, 1988). Previous studies had shown that transient levels of secretory amylase and ribonuclease are also secreted in response to 3-adrenergic stimuli, suggesting that these too may be present in the Type III cells (Ball, 1974a, Ball andNelson, 1978a,b).…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

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Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

179

171

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The major salivary glands of mammals are represented by three pairs of organs that cooperate functionally to produce saliva for the oral cavity. While each type of gland produces a signature secretion that complements the secretions from the other glands, there is also redundancy as evidenced by secretion of functionally similar and, in some cases, identical products in the three glands. This, along with their common late initiation of development, in fetal terms, their similarities in developmental pattern, and their proximate sites of origin, suggests that a common regulatory cascade may have been shared until shortly before the onset of overt gland development. Furthermore, occasional ectopic differentiation of individual mature secretory cells in the wrong" gland suggests that control mechanisms responsible for the distinctive cellular composition of each gland also share many common steps, with only minor differences providing the impetus for diversification. To begin to address this area, we examine here the origins of the salivary glands by reviewing the expression patterns of several genes with known morphogenetic potential that may be involved based on developmental timing and location. The possibility that factors leading to determination of the sites of mammalian salivary gland development might be homologous to the regulatory cascade leading to salivarv gland formation in Drosophila is also evaluated. In a subsequent section, cellular phenotypes of neonatal and adult glands are compared and evaluated for insights into the mechanisms and lineages leading to cellular diversification. Finally, the phenomena of proliferation, repair, and regeneration in adult salivary glands are reviewed, with emphasis on the extent to which the cellular diversity is reversible and which cell type other than stem cells has the ability to redifferentiate into other cell types.

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Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

179

171

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“…Both branches of the autonomic nervous system innervate the major salivary glands of the rat [17]. The parasympathetic nerves are able to activate secretion at birth in the submandibular gland, whereas the sympathetic nerves reach the submandibular gland by postnatal day 5 and activate secretion beginning on postnatal day 6 [2,11]. ß-Receptors are found on the surface of secretory cells as early as day 1 after birth [5]; between days 4 and 6, the number of ß-receptors increases 4-fold concomitantly with nerves containing catecholamines growing into the parenchyma of the submandibular glands [2,11].…”

Section: Discussionmentioning

confidence: 99%

“…The parasympathetic nerves are able to activate secretion at birth in the submandibular gland, whereas the sympathetic nerves reach the submandibular gland by postnatal day 5 and activate secretion beginning on postnatal day 6 [2,11]. ß-Receptors are found on the surface of secretory cells as early as day 1 after birth [5]; between days 4 and 6, the number of ß-receptors increases 4-fold concomitantly with nerves containing catecholamines growing into the parenchyma of the submandibular glands [2,11]. Cutler et al [12] demonstrated that chemical sympathectomy has no effect on the time of appearance or number of ß-adrenoreceptors in neonatal glands, indicating that the presence of catecholamine-containing nerves within the submandibular gland is not a requisite for the appearance of ß-adrenergic receptors.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Sympathetic Innervation on Isoproterenol-Induced Cystatin S Gene Expression in Rat Submandibular Glands during Early Development

Chaparro

Shaw

1998

Dev Neurosci

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The rat submandibular gland is innervated by both sympathetic and parasympathetic branches of the autonomic nervous system which, in turn, regulate the secretory function of the gland. Parasympathetic innervation of rat submandibular glands is present at birth; in contrast, sympathetic innervation reaches the glands by postnatal day 5. Isoproterenol (IPR), a β-adrenoreceptor agonist, induces hypertrophic and hyperplastic enlargement of rat salivary glands, and induces the expression of a number of genes, including cystatin S (Cys S), a member of family 2 of the cysteine proteinase inhibitor superfamily. Cys S gene expression is tissue specific, cell type specific, occurs temporally during normal development and is not observed in adult animals unless stimulated by IPR. In addition, sympathectomy of adult rat submandibular glands reduced IPR-induced expression of the Cys S gene. This paper reports experiments analyzing the participation of the sympathetic branch of the autonomic nervous system in IPR-induced expression of the cystatin S gene during early development of the submandibular gland. The rat Cys S gene could be induced by IPR by day 3, and the level of Cys S mRNA remained constant until 8 days at which time a dramatic IPR induction of Cys S mRNA was observed. This statistically significant increase in Cys S mRNA at 8 days was diminished, but not completely suppressed, upon sympathectomy of 1-day-old animals. These data indicate that an intact sympathetic innervation is not a requisite for IPR-induced Cys S gene expression in developing submandibular glands; however, sympathetic innervation is required for the full IPR response of the Cys S gene in developing submandibular glands. The developmental experiments presented in this paper indicate that factor(s) coming from the sympathetic nervous system participate in IPR-induced expression of the Cys S gene in rat submandibular glands.

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Accumulation and localization of two adult acinar cell secretory proteins during development of the rat submandibular gland

et al. 1991

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The seromucous acinar cells of the adult rat submandibular gland secrete a characteristic mucin glycoprotein and a family of unusual glutamine/glutamic acid-rich proteins (GRP). Monoclonal antibodies to the mucin and GRP localized in a very few Type III cells in glands of newborn and 1 day-old rats, using light and electron microscopic immunocytochemistry. Both mucin and GRP reactivities were present in the polymorphic Type IIIP granules during the 1st postnatal week. By 9 days after birth, the granules contained both mucin and GRP and were mucous-like in appearance. At earlier stages, however, cells containing only GRP or mucin could be found, indicating that the initiation of GRP and mucin biosynthesis may not be coordinately regulated. No reactivity was seen in the neonatal Type I cells or in duct cells at any age. Northern and Western blot analysis showed GRP mRNA and protein levels to be barely detectable at birth, with marked increases during the first 2 postnatal weeks. In contrast, Western blots of B1-immunoreactive proteins (B1-IP) showed levels highest in the 1st week and markedly decreased in the adult. Immunocytochemical colocalization, using gold particles of different sizes, showed that the B1-IP, mucin, and GRP colocalized in the granules. These results strengthen the hypothesis that the adult acinar cells develop from the neonatal Type III cells. No evidence was obtained for the involvement of Type I cells in the pathway of acinar cell development.

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Chapter 32 Development of Stimulus—Secretion Coupling in Salivary Glands

Cited by 23 publications

References 44 publications

Salivary Glands: A Paradigm for Diversity of Gland Development

Salivary Glands: A Paradigm for Diversity of Gland Development

Effect of Sympathetic Innervation on Isoproterenol-Induced Cystatin S Gene Expression in Rat Submandibular Glands during Early Development

Accumulation and localization of two adult acinar cell secretory proteins during development of the rat submandibular gland

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